Tokyo Metropolitan Industrial Technology Research Institute

Gunma University

Nitta Gelatin Inc.

Yoshimi Ohyabu

Shunji Yunoki

Naohisa Yahagi

Toshio Uraoka

Takefumi Narita

Hirosuke Hatayama

Masataka Ida

Yosuke Hiraoka

The purpose of the present invention is to provide an injectable sol into a body, suited for delivery through a catheter, and usable for tissue perforation closure, ulcer protection, or vascular embolization. Provided are a sol for tissue perforation closure, a sol for ulcer protection, and a sol for vascular embolization, each containing from 0.6 mass % to 3 mass % of a collagen, water, from 200 mM to 330 mM sodium chloride, and a buffer and having a pH from 6.0 to 9.0.

Sol for tissue perforation closure, ulcer protection, and vascular embolization

Object of the present invention is to provide a safe sol for submucosal local injection which gels and creates a mucosal elevation having a high retention rate of mucosal elevation height when locally injected into a digestive submucosa. Provided is a sol for submucosal local injection containing from 0.2 mass % to 1.2 mass % of a collagen, water, a buffer, and from 200 mM to 420 mM sodium chloride.

Collagen sol for submucosal local injection

A gelatin or a chemically modified product thereof contains 10 to 50% by mass of a high-molecular weight component, and a low-molecular weight component in such an amount that a value obtained by subtracting a low-molecular weight component content from a high-molecular weight component content is greater than or equal to 0% by mass.

Gelatin, chemically modified product thereof, aqueous composition and medical laminate containing same, production method for medical laminate, and cell sheet isolation method

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Tokyo, Japan

Yoshimi Ohyabu