Nagasaki University

Ono Pharmaceutical Co., Ltd.

Kabushiki Kaisha Komatsu Seisakusho

Yoshimasa Tanaka

Nagahiro Minato

Shiro Shibayama

Hiroshi Ueda

Yuki Sakai

Satoshi Mizuta

Kenji Matsumoto

Kazumori Nishida

Toshinori Kawahashi

Kosuke Hayashi

The novel bisphosphonic acid ester derivatives represented by the following formula (1):Y&#x2014;Cy&#x2014;(NH)&#x2014;(CH)&#x2014;C(X)(PO(OR)(OR))&#x2003;&#x2003;(1)wherein each symbol is as defined in the DESCRIPTION, which has an amino group substituted by a heterocyclic group or a heterocyclic group containing a nitrogen atom, and the acid moiety is esterified with a POM group, an n-butanoyloxymethyl (BuOM) group and the like, exhibit a superior direct or indirect cytotoxicity effect on tumor cells and virus infected cells.

Bisphosphonic acid derivative and application for same

A series of fluorine-containing bisphosphonic acids in which an alkylamine side chain is added, a series of fluorine-containing bisphosphonic acids in which an amino group substituted by a heterocyclic group or a heterocyclic group containing a nitrogen atom is added, to the carbon atom of P&#x2014;C(F)&#x2014;P, and a series of fluorine-containing bisphosphonate derivatives in which the acid moiety thereof is esterified by an alkoxymethyl group such as POM group, n-butanoyloxymethyl (BuOM) group and the like, that is, the fluorine-containing bisphosphonic acid and fluorine-containing bisphosphonate derivative represented by the following formula (I): wherein each symbol is as defined in the DESCRIPTION, can efficiently induce proliferation of peripheral blood &#x3b3;&#x3b4; T cells that express V&#x3b3;2V&#x3b4;2 T cell receptor having superior cytotoxicity against tumor cells and virus infected cells, immunize tumor cells and virus infected cells, and can induce cytotoxicity by &#x3b3;&#x3b4; T cells.

Fluorine-containing bisphosphonic acid derivative and use thereof

The present invention aims to provide a novel compound for measuring cellular cytotoxicity or cell proliferation capacity accurately with high reproducibility, conveniently and rapidly, and a measurement method of cellular cytotoxicity or cell proliferation capacity by using the compound. The present invention relates to a compound represented by the formula (I): wherein Ris a substituent, Rand Rare each an optionally substituted hydrocarbon group, or an optionally substituted heterocyclic group, Y is a substituent, n is an integer of 0-3, Z is a single bond, &#x2014;O&#x2014;, &#x2014;S&#x2014;, &#x2014;SO&#x2014;, &#x2014;SO&#x2014;, or &#x2014;NR&#x2014; (Ris a hydrogen atom or a substituent), and A is an optionally substituted Calkylene group) or a salt thereof.

Rapid method for measuring cytotoxicity in non-RI system

As a substance which pharmacologically regulates the function of a cell surface functional molecule, a substance which has specificity and an activity or efficacy equal or superior to an antibody and does not require an advanced production technique and facility for application thereof to a pharmaceutical product has been demanded. The invention relates to a multimer of an extracellular domain of a cell surface functional molecule, particularly a tetramer of an extracellular domain of PD-1 or PD-L1. Further, the invention relates to an application of such a tetramer as a preventive and/or therapeutic agent for cancer, cancer metastasis, immunodeficiency, an infectious disease or the like and an application of PD-1 or PD-L1 as a testing or diagnostic agent or a research agent for such a disease.

Multimer of extracellular domain of cell surface functional molecule

An operating device for a double drum winch that has a hydraulically operated clutch, a brake and a hydraulic pressure variable control valve, and a single control lever connected to the hydraulic pressure variable control vavle to enable the operation of a hook and boom by one control lever so as to simplify the function and uses of the winch.

Growing community of inventors

Nagasaki, Japan

Yoshimasa Tanaka