Jcr Pharmaceuticals Co., Ltd.

Yoshiko Yoshii

Hiroyuki Sonoda

Yuri Koshimura

Hideto Morimoto

Masafumi Kinoshita

Haruna Takagi

Disclosed are a novel anti-human transferrin receptor antibody comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 4, 5, 6 and 7 that can pass through the blood-brain barrier, a fusion protein comprising a protein necessary to be brought into function in the central nervous system and the antibody, and method of their production. The fusion protein comprises amino acid sequences of an anti-human transferrin receptor antibody that recognizes an amino acid sequence selected from the group consisting of SEQ ID NOs:1, 2, and 3, and of other protein that is bound thereto on the C-terminal side.

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Hyogo, Japan

Yoshiko Yoshii