Suntory Holdings Limited

Suntory Limited

Yoshiko Ono

Daisuke Takemoto

Kengo Akimoto

Hiroshi Kawashima

Namino Tomimori

Harukazu Fukami

Yuko Fukui

Norifumi Tateishi

Akifumi Maeda

Yoko Yasutake

Koichi Nakahara

Mitsuru Maeda

Kayo Saito

Katsuya Nagai

Daisuke Yamada

Yoshinobu Kiso

Yoshiyuki Ishikura

Toshihiro Nishiumi

Masanori Kontani

Hiroshige Okaichi

Mineko Kato

Yuki Yagita

Chie Abe

Youko Okaichi

Chika Horikawa

Yasuo Matsumura

The present invention aims to provide a highly safe composition that can be used for improving or maintaining mitochondrial function and/or mitochondrial energy production capacity or reducing a decline in mitochondrial function and/or mitochondrial energy production capacity and that allows easy intake and continuous ingestion without risk of side effects. The present invention also aims to provide, for example a method of improving or maintaining mitochondrial function and/or mitochondrial energy production capacity or reducing a decline in mitochondrial function and/or mitochondrial energy production capacity. The present invention relates to, for example, a composition containing at least one sesamin-class compound and pyrroloquinoline quinone (PQQ) or a salt thereof.

Composition containing sesamin and PQQ

The object of the present invention is to provide a composition that has preventive or ameliorative action on symptoms or diseases caused by decreased brain function. This composition contains, as its active ingredient, arachidonic acid and/or a compound having arachidonic acid as a constituent fatty acid and, particularly, an alcohol ester of arachidonic acid or a triglyceride, phospholipid or glycolipid in which all or a portion of the constituent fatty acids are arachidonic acid.

Composition having effects of preventing or ameliorating conditions or diseases caused by brain hypofunction

The present invention relates to a composition containing riboflavin and a sesamin-class compound(s). This composition may incorporate a sesamin-class compound(s) in such an amount that the proportion (weight ratio) of its total quantity to the total quantity of riboflavin taken as unity is no more than 4.5, and it has the advantage that the analgesic and anti-fatigue actions of riboflavin are synergistically improved by ingestion of riboflavin in combination with a sesamin-class compound(s). The composition of the present invention provides compositions, in particular, pharmaceuticals as well as foods and beverages that are safe to humans, animals, etc., and can therefore be ingested for a continued period, and which have far superior effects to those of conventional foods having an analgesic or anti-fatigue action.

Compositions containing riboflavin and sesamin-class compounds

A composition having a normalizing action for infradian rhythm and/or a synchronization promoting action for circadian rhythm (biological clock) containing arachidonic acid and/or an arachidonic acid-containing compound.

Composition for normalization of infradian rhythm

Anti-fatigue agents containing dioxabicyclo[3.3.0]octane derivatives such as sesamin which is an ingredient contained in sesame, as well as pharmaceutical compositions and physiologically functional foods that contain such anti-fatigue agents are disclosed. These compounds can safely be administered to humans and animals alike and hence allow for continued ingestion while proving effective in promoting an improvement of stamina, an increase of body strength, a relief of fatigue, and recovery from fatigue.

Anti-fatigue agent

A composition incorporating at least one sesamin-class compound is enhanced in the anti-fatigue action of sesamin class compounds by additionally incorporating at least one vitamin Bclass compound. Also provided is an anti-fatigue agent containing at least one sesamin-class compound and at least one vitamin Bclass compound as the active ingredients.

Compositions incorporating sesamin-class compounds and vitamin B1 class compounds

An object of the present invention is to increase the rate at which lignan-class compounds are absorbed into the body, namely, to provide fast-acting lignan-class compounds. Provided is an oil-in-water emulsion which comprises a water phase and an oil phase comprising at least one kind of lignan-class compounds dissolved therein and being emulsified in the water phase, wherein the oil droplets which serve as a dispersion phase in the emulsion are made finer by high-speed agitation or other method so that their average particle size is 1000 nm or smaller, preferably 500 nm or smaller, and more preferably 300 nm or smaller, whereby the rate at which lignan-class compounds are absorbed into the body is improved to impart immediate action.

Oil-in-water emulsions containing lignan-class compounds and compositions containing the same

A method by which the physiological activities of sesamin-class compounds can be efficiently exhibited and enhanced, as well as an effective compound that can be combined with the sesamin-class compounds to this end. By using sesamin-class compounds in combination with more than specified proportions of arachidonic acid class compounds, the physiological activities of the sesamin-class compounds, for example, their anti-fatigue action is synergistically enhanced to provide compositions that are safe in humans and non-human animals and which hence can be ingested continuously.

Compositions containing sesamin-class compound(s) and arachidonic acid class compound(s)

The purpose of the present invention is to provide a means of enhancing the bodily absorption of sesamin-class compounds. By using sesamin-class compounds and quercetin glycosides in combination, the bodily absorption of the sesamin-class compounds can be enhanced.

Compositions containing sesamin-class compound(s) and quercetin glycoside(s)

The present invention provides a circadian rhythm normalizing composition containing astaxanthin and/or its ester as an active ingredient, and a composition having the action of enhancing the circadian rhythm normalizing action of melatonin by protecting melatonin. The composition can be in the form of a drug, a functional food, a food or a beverage. This composition has a circadian rhythm normalizing action, and has the action of preventing or alleviating sleep disorder and various diseases due to disturbance of the circadian rhythm.

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Osaka, Japan

Yoshiko Ono