Fujisawa Pharmaceutical Company, Ltd.

Yoshiko Inamoto

Kazuo Sakane

Kohji Kawabata

Kenzi Miyai

Takao Takaya

The invention relates to a compound of the formula: ##STR1## of antimicrobial activity.

Cephem compounds and pharmaceutically acceptable salts thereof

The invention relates to compounds, useful as intermediates in the preparation of products of antimicrobial activity, of the formula: ##STR1## wherein R.sup.3 is hydrogen, lower alkyl, hydroxy(lower)alkyl, protected hydroxy(lower)alkyl, amino(lower)alkyl, protected amino (lower) alkyl, carbamoyl)lower)alkyl, N,N-di(lower) alkylcarbamoyl(lower)alkyl or an amino protective group, and

Intermediates for cephem compounds

Cephem compounds of the following formula are disclosed: ##STR1## wherein R.sup.1 is amino or protected amino group. R.sup.2 is H or an organic group,

Cephem compounds

The invention relates to antimicrobial compounds of the formula: ##STR1## wherein R.sup.1 is amino or a protected amino, R.sup.2 is ethyl, propyl or lower alkenyl,

Cephem compound

The invention relates to an antimicrobial compound of the formula: ##STR1## wherein R.sup.1 is amino or a protected amino group,

The object of the invention is a new cephem compound with antimicrobial activity used for the treatment of infectious diseases of the general formula: ##STR1## wherein R1 is amino or a protected amino

Cephem compound and a process for preparation thereof

The invention relates to an antimicrobial agent of the formula: ##STR1## wherein R.sup.1 is amino or conventional protected amino, R.sup.2 is hydrogen or tetrahydropyranyl, and ##STR2## wherein R.sup.4 is lower alkyl, and R.sup.5 is hydrogen or lower alkyl substituted with hydroxy or conventional protected hydroxy, and pharmaceutically acceptable salts thereof.

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Toyonaka, Japan

Yoshiko Inamoto