Sekisui Chemical Co., Ltd.

Yoshiko Abe

Takayuki Akamine

Saori Tone

Kazushi Itou

Kiyoshi Kuriyama

Koji Inagaki

Akihiko Fujiwara

Daichi Kawamura

A particle comprising a first fraction containing an active ingredient and a second fraction containing a surfactant, and having a number average particle diameter of from 1 to 100 nm.

Preparation

The present invention provides a core-shell structure having high skin permeability. The core-shell structure includes a core portion containing a hydrophilic drug having a molecular weight of 400 or more; and a shell portion containing a surfactant, and the core portion is a solid, the hydrophilic drug has a water-octanol partition coefficient of &#x2212;3 or more and 6 or less, the surfactant has an alkyl group or an alkenyl group having 10 to 20 carbon atoms, and a mass ratio between the hydrophilic drug and the surfactant (hydrophilic drug:surfactant) is 1:5 to 1:20.

Core-shell structure and topical agent

An object is to provide a formulation that includes a particle containing an active ingredient and a surfactant, and a base, and is more excellent in storage stability. For solution, a formulation including a particle containing an active ingredient and a surfactant, and a base, in which the surfactant is contained in a ratio of 5 to 100 parts by weight based on 1 part by weight of the active ingredient, is provided.

Formulation and method for producing same

The object of the present invention is to provide a dermal composition for external use which keeps skin healthy and demonstrates a sufficient effect in treating skin diseases. The present invention relates to a dermal composition for external use, which comprises sodium cromoglycate and a monoester of polyvalent alcohol and salicylic acid contained in a base.

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Tokyo, Japan

Yoshiko Abe