Nitto-denko Corporation

Osaka University

Sumitomo Electric Industries, Limited

Hokkaido University

Yoshiki Maeda

Haruo Sugiyama

Mitsuhiko Hori

Daisuke Asari

Takuya Shishido

Katsuyuki Okubo

Arimichi Okazaki

Kyohei Matsushita

Hideyoshi Harashima

Mitsunori Kobayashi

Yoshikatsu Mori

Yoshihiko Doi

Yusuke Sato

Masamitsu Taguchi

Sachiko Sakamoto

Wenjing Li

Mitsuaki Noda

Naruhito Yauchi

Kazuki Hashiba

Ayaka Otsu

The present invention addresses the problem of providing lipid nanoparticles which function as gene transfer carriers capable of selective transfer to the liver or spleen. Lipid nanoparticles which contain a pH-sensitive cationic lipid represented by formula (I) [a represents an integer of 3-5; b represents 0 or 1; Rand Reach independently represent a group represented by general formula (A) (Rand Reach independently represent a linear or branched Calkyl group; c represents 0 or 1; v represents an integer of 4-12); and X represents a group represented by general formula (B)(d represents an integer of 0-3; and Rand Reach independently represent a Calkyl group or Calkenyl group, while Rand Rmay form a 5- to 7-membered non-aromatic heterocycle) or represents a 5- to 7-membered non-aromatic heterocyclic group]. (I) (R)(R)C(OH)—(CH)a-(O—CO)b-X. (A): (R)(R)—CH—(CO—O)c-(CH)v-. (B):—(CH)d-N(R)(R).(R)(R)C(OH)—(CH)—(O—CO)-X  (I)(R)(R)—CH—(CO—O)—(CH)-  (A)—(CH)-N(R)(R)  (B)

Lipid nanoparticle

The present invention provides a cancer vaccine composition for transdermal administration for inducing cellular immunity, comprising (i) a WT1 peptide and/or a modified WT1 peptide; and (ii) a cellular immunity induction promoter. The composition efficiently induces cellular immunity against a cancer in a subject.

WT1 peptide cancer vaccine composition for transdermal administration

The present invention provides a cancer vaccine composition for mucosal administration for inducing cellular immunity, comprising (i) a WT1 peptide and/or a modified WT1 peptide; and (ii) a cellular immunity induction promoter. The composition efficiently induces cellular immunity against a cancer in a subject.

WT1 peptide cancer vaccine composition for mucosal administration

The present invention provides a cancer vaccine tape preparation for inducing cellular immunity, comprising:

Tape preparation of WT1 peptide cancer vaccine for transdermal administration

The invention provides a vaccine composition containing an antigen for inducing cellular immunity, comprising at least one first cellular immunity induction promoter.

Vaccine composition

The present invention provides a cancer vaccine composition for transdermal administration for cellular immunity induction, comprising (i) a WT1 peptide and/or a modified WT1 peptide; and (ii) a pharmacologically acceptable acid as a first cellular immunity induction promoter, or a pharmacologically acceptable salt thereof.

A throw-away insert has four sets of cutting edges with high edge strength and which does not limit the amount which can be cut. An upper half portion of the insert has a set of cutting edges provided at each of two acute-angled corners of a parallelogram. The set of cutting edges includes a major cutting edge defined on one side of the parallelogram and a minor cutting edge defined on the other side and forming an angle of about 90.degree. with the major cutting edge. The lower half portion of the insert has the same structure and dimensions as the upper half portion but is configured as if the upper portion were turned over and further rotated 3.degree.-7.degree. clockwise with respect to the upper half portion. The two sets of cutting edges on the upper half portion and the two on the lower half portion constitute four sets of cutting edges in all.

Throw-away insert and face milling cutter

The present invention relates to a process of physical vapor deposition which homogeneously and tightly coats hard compounds on the surface of cutting tools, parts requiring wear resistance or ornaments such as a watch case and the like in order to improve wear resistance, heat resistance, corrosion resistance, appearance and the like of said tools, parts or ornaments. The present invention can provide a method of physically coating a solid solution consisting of at least one compound selected from the group consisting of carbides, nitrides or oxides of metals belonging to IVb, Vb and VIb groups of the Periodic Table and/or aluminum oxide and zirconium oxide on the surface of said tools, parts or ornaments in the form of a single layer or multiple-layers, wherein the surface of said tools and the like is subjected to sputter cleaning in the atmosphere of hydrogen or the gaseous mixture of hydrogen and inert gas wherein hydrogen is present at 20% by volume or more, to homogeneously clean said surface of said tools and the like and as a result, the adhesion of the coating consisting of said compounds on said tools and the like is improved and equalized. Thus the above-mentioned properties of said tools and the like is further improved.

Growing community of inventors

Osaka, Japan

Yoshiki Maeda