Daiichi Sankyo Company, Limited

Yoshikazu Uto

Yasuyuki Ogawa

Kazumasa Aoki

Osamu Iwamoto

Hidenori Takahashi

Mikio Kato

Hiroko Kono

Kiyosumi Takaishi

Hiroshi Karasawa

Iwamoto,osamu

It is an object of the present invention to provide a medicament for preventing or treating hyperphosphatemia. Solution: A compound represented by a general formula (I) or a pharmacologically acceptable salt thereof. (In the formula, R: a methyl group or the like, R: a hydrogen atom or the like, R: a hydrogen atom or the like, A: a cyclohexyl ring or the like, X: CH or the like, Y: CH or the like, Z: CH or the like, and n: 2 or the like).

Dicarboxylic acid compound

It is an object of the present invention to provide a medicament for preventing or treating hyperphosphatemia. Solution: A compound represented by a general formula (I) or a pharmacologically acceptable salt thereof. [In the formula, R: a methyl group or the like, R: a hydrogen atom or the like, R: a hydrogen atom or the like, A: a cyclohexyl ring or the like, X: CH or the like, Y: CH or the like, Z: CH or the like, and n: 2 or the like].

The present invention relates to a compound or a pharmacologically acceptable salt thereof having an excellent DGAT inhibitory effect and feeding suppressant effect. The present invention provides a compound represented by the general formula (I), or pharmacologically acceptable salt thereof: [wherein,Rrepresents a phenylaminocarbonyl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group A, a benzoxazol-2-yl group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group A, or the like; Rindependently represents a C-Calkyl group; Rrepresents a group represented by the formula &#x2014;C(&#x2550;O)&#x2014;O&#x2014;Ror the like; Rrepresents a hydrogen atom, a C-Calkyl group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group B, or the like; X represents an oxygen atom, a methylene group, or a group represented by the formula &#x2014;NH&#x2014;, or the like; L represents a single bond, a methylene group, or the like; . . . represents a single bond or a double bond; m represents 1 or 2; n represents an integer of 0 to 5; Substituent Group A represents a halogen atom, a C-Calkyl group, a C-Chalogenated alkyl group, a C-Calkoxy group, or the like; and Substituent Group B represents a C-Ccycloalkyl group, a phenyl group, a carboxyl group, or the like].

Tetrahydroisoquinoline derivative

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Tokyo, Japan

Yoshikazu Uto