Eisai Company, Limited

Yoshikazu Suzuki

Isao Yamatsu

Takeshi Suzuki

Shinya Abe

Yuichi Inai

Osamu Tagaya

Kouji Yamada

Akiharu Kajiwara

Seiichi Araki

Masaichi Yamamoto

Haruyoshi Arai

Kouichi Suzuki

Hiroshi Yamamoto

Kouichi Abe

Koichi Abe

Nozomu Koyanagi

A &bgr;,&ggr;-dihydropolyprenyl alcohol derivative having the formula:

&bgr;,&ggr;-dihydropolyprenyl alcohol derivatives and pharmaceutical composition containing a polyprenyl compound

A .beta.,.gamma.-dihydropolyprenyl alcohol derivative having the formula: ##STR1## wherein n is an integer of 5 to 7 and R is hydrogen, a lower alkyl group or an aliphatic or aromatic acyl group, is new and useful as a prophylactic therapeutic agent for human and animal immuno-deficiency deseases and phylactic agent against human and animal infectious deseases. Another disclosed polyprenyl compound is also useful as the same agent.

Beta, gamma-dihydropolyprenyl alcohol derivatives and pharmaceutical

Various .beta.,.gamma.-dihydropolyprenyl alcohol derivatives having the formula: ##STR1## wherein n is an integer of 5 to 7 and R is hydrogen, a lower alkyl group or an aliphatic or aromatic acyl group are effective at pritigating stress in animals.

.beta., .gamma.-dihydropolyprenyl alcohol derivatives effective at

A .beta.,.gamma.-dihydropolyprenyl alcohol derivative having the formula: ##STR1## wherein n is an integer of 5 to 7 and R is hydrogen, a lower alkyl group or an aliphatic or aromatic acyl group, is new and usrful as a prophylactic therapeutic agent for human and animal immuno-deficiency deseases and phylactic agent against human and animal infectious deseases. Another disclosed polyprenyl compound is also useful as the same agent.

.beta.,.gamma.-dihydropolyprenyl alcohol derivatives and pharmaceutical

A novel compound, 3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid, and a salt thereof are disclosed together with a number of different processes for the preparation of the compound. The uses of the novel compound as an agent for treating papillomata are also disclosed.

3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid composition

Skin diseases with keratinization and allergic or inflammatory skin diseases are treated by orally or parenterally administering to an adult human patient from 40 mg to 4 g/day of a polyprenyl compound having the formula (I): ##STR1## in which each of n and m is 0, 1, or 2, n+m is 0, 1 or 2, A is ##STR2## and B is ##STR3## [in which R represents the hydroxyl group, a lower alkoxy group, or ##STR4## (wherein each of R.sub.1 and R.sub.2 is the hydrogen atom, a lower alkyl group or an aryl group)]; provided that R is a lower alkoxy or ##STR5## if n is 1, m is 0, a is ##STR6## and B is ##STR7##

Method of treating skin diseases

A novel compound, 3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid, and a salt thereof are disclosed together with a number of different processes for the preparation of the compound. The uses of the novel compound as an anticancer agent are also disclosed.

3,7,11,15-Tetramethyl-2,4,6,10,14,-hexadecapentaendic acid

An anti-cancer agent which comprises a polyprenvl compound having the formula (I): ##STR1## in which each of n and m is 0, 1 or 2, n+m is 0, 1 or 2, A is ##STR2## and B is ##STR3## in which R represents the hydroxyl group, a lower alkoxy group, or ##STR4## (wherein each of R.sub.1 and R.sub.2 is the hydrogen atom, a lower alkyl group or an aryl group)]; provided that R is a lower alkoxy or ##STR5## if n is 1, m is 0, A is ##STR6## and B is ##STR7##

Method of treating cancerous and precancerous conditions

A conjugated polyprenylcarboxylic acid and its derivative having the formula: ##STR1## in which each of n and m is 0, 1 or 2, n+m is 1 or 2, A is ##STR2## and R is the hydroxyl group, a lower alkoxy group or ##STR3## wherein each of R.sub.1 and R.sub.2 represents the hydrogen atom, a lower alkyl group, or an aryl group; provided that R is ##STR4## if A is ##STR5## n is 1 and m is 0.

Conjugated polyprenylcarboxylic acids and their derivatives

A .beta.,.gamma.-dihydropolyprenyl alcohol derivative having the formula: ##STR1## wherein n is an integer of 5 to 7 and R is hydrogen, a lower alkyl group or an aliphatic or aromatic acyl group, is new and useful as a phylactic agent against human and animal infectious diseases. Other disclosed polyprenyl compounds are also useful as such agents.

The polyprenyl compound having the formula: ##STR1## wherein X represents a group of the formula: --CH.dbd.CH--, a group of the formula: ##STR2## or a group of the formula: ##STR3## and Y represents a group of the formula: --COOR.sup.1 in which R.sup.1 represents a hydrogen atom or a lower alkyl group or a group of the formula: ##STR4## in which R.sup.2 represents a hydrogen atom or a lower alkyl group, is new and useful as a medicine.

Polyprenyl compounds

A compound, 3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid, and a salt thereof are disclosed as a therapeutic agent for treatment of skin diseases with keratinization.

Growing community of inventors

Ichinomiya, Japan

Yoshikazu Suzuki