Central Glass Company, Limited

Yoshikazu Sugimori

Toshikazu Kawai

Naoto Takada

Junji Negishi

Yasunobu Nishimura

Masataka Fujimoto

Fumiyoshi Yoshikawa

Masanori Tsukamoto

The invention relates to a process for producing 1,1,1-trifluoroacetone, which is useful as an intermediate of pharmaceuticals and agricultural chemicals, or as a reagent for introducing fluorine-containing groups. This process includes the step of conducting a hydrogenolysis of a halogenated trifluoroacetone, which is represented by the formula [1], by a hydrogen gas, in a liquid phase containing water, in the presence of a catalyst containing a transition metal, where X represents a chlorine, bromine or iodine, and n represents an integer from 1 to 3. It is possible by the process to easily produce 1,1,1-trifluoroacetone with high purity.

Process for producing 1,1,1-trifluoroacetone

In preparing trifluoromethylbenzonitrile by reaction of trifluoromethylbenzaldehyde with hydroxylamine, the rate of reaction is enhanced and formation of trifluoromethylbenzamide is suppressed by carrying out the reaction in an organic solvent which is immiscible with water and has a sufficiently high boiling point, e.g. nitrotoluene, and continuously distilling by-produced water from the reaction system. The solvent can easily and almost entirely be recovered and reused.

Preparation of trifluoromethylbenzonitrile from

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Saitama, Japan

Yoshikazu Sugimori