Otsuka Pharmaceutical Company, Limited

Yoshikazu Shimada

Takashi Hayashi

Masayuki Takahashi

Yasuhiro Abiru

Ikutaro Sato

Tadaaki Ohtani

Setsuko Yasuda

Norihiro Miyazawa

Kouichi Ozaki

Tsutomu Fujiwara

Masato Horie

Sadahito Shin, Deceased

Masami Nagata

Satoshi Takeda

An object of the present invention is to provide enzymes associated with equol synthesis, genes coding such enzymes, and a process for producing equol and its intermediates using the enzymes and genes. The present invention provides a dihydrodaidzein synthesizing enzyme, tetrahydrodaidzein synthesizing enzyme, equol synthesizing enzyme, and genes coding these enzymes. The present invention also provides a process for synthesizing dihydrodaidzein, tetrahydrodaidzein, and/or equol using these enzymes.

Enzyme associated with equol synthesis

Isolated DNA molecule encoding human TSC403

An isolated hTFIIIA gene having a nucleotide sequence coding for the amino acid sequence of SEQ ID NO:1, as disclosed, and in particular the hTFIIIA gene having the nucleotide sequence of SEQ ID NO:2. The gene can be used to express a corresponding hTFIIIA protein. The gene and protein serve as transcription regulating factors, and are useful in the diagnosis or identification of hereditary disease, such as cancer or other diseases resulting from abnormal transcriptional control and, further, in analyzing the mechanisms of action thereof.

hTFIIIA gene

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Osaka, Japan

Yoshikazu Shimada