Otsuka Pharmaceutical Company, Limited

Yoshikazu Oka

Tadashi Mukai

Yuso Tomohira

Keigo Yamada

Minoru Kashimoto

Daisuke Kuribayashi

Masakazu Nagasawa

Tetsuroh Ichiba

Hajime Toguchi

Masafumi Toda

Tetsuroh 59-15 Aza Sumiyoshikaitaku Ichiba

Disclosed is a method for stabilizing a solid pharmaceutical preparation containing a pharmacological substance and sodium lauryl sulfate, the method comprising incorporating into the preparation at least one member selected from the group consisting of neutral salts, basic salts and basic substances. The preparation containing sodium lauryl sulfate prepared by the method of the invention has superior performance, including high storage stability, suppression of discoloration and deterioration, and prevention of change in its properties, such as the dissolution rate of pharmacological substance from the preparation.

Method for stabilizing preparation

Provided is a cilostazol preparation which comprises incorporating a fine powder of cilostazol into a dispersing and/or solubilizing agent thereby to enhance the dispersibility and/or solubility. Further, provided is a process for improving absorbability of a slightly soluble drug such as cilostazol even at the lower portion of the digestive tract, wherein said drug is hard to be absorbed at the lower portion of the digestive tract when a conventional method is used. According to the present invention, cilostazol is absorbed enough even at the lower portion of the digestive tract to have an effect as thrombolytic drug, cerebral circulation improving drug or the like.

Cilostazol preparation

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Tokushima, Japan

Yoshikazu Oka