Takeda Chemical Industries, Inc.

Senju Pharmaceutical Co., Ltd.

Yoshikazu Oka

Akio Miyake

Kohei Nishikawa

Katsumi Itoh

Minoru Hirata

Norio Tada

Mitsumi Tomimoto

Sukehiro Chiba

New bicyclic compounds, inclusive of salts thereof, of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and each represents hydrogen, hydroxyl or lower alkoxy, R.sup.3 is hydrogen or lower alkyl, R.sup.4 is hydrogen, lower alkyl, amino-lower-alkyl or acylamino-lower-alkyl, R.sup.5 is hydrogen, lower alkyl or aralkyl which may be substituted, R.sup.6 is hydroxyl, lower alkoxy, amino or lower alkylamino, and m and n each means 1 or 2, have inhibitory activities of angiotensin converting enzyme and bradykinin decomposing enzyme, and are useful as antihypertensive agents.

Process for preparation of bicyclic compounds

Bicycle compounds, their production and use

Novel compounds of the formula: ##STR1## wherein R is phenyl-C.sub.1-6 alkyl, and salts thereof, have intraocular pressure depressant action.

Naphthalenecarboxamides, their production and use

New bicyclic compounds, inclusive of salts thereof, of the formula: ##STR1## wherein R.sup.1 and R.sup.2, which may be the same or different, each represent hydrogen, halogen, lower alkyl, hydroxyl, lower alkyloxy or aralkyloxy, or R.sup.1 and R.sup.2 jointly represent lower alkylenedioxy; R.sup.3 and R.sup.4 each represent hydrogen or lower alkyl; R.sup.5 represents hydrogen, lower alkyl or --CH.sub.2 SR.sup.7 (R.sup.7 represents hydrogen or acyl); R.sup.6 represents hydrogen or acyl, or R.sup.6 and R.sup.7 jointly represent a single bond; X represents --CH.sub.2 --, --O-- or &gt;N--R.sup.8 (R.sup.8 represents hydrogen, acyl or lower alkyl); and n represents 2, 3 or 4, have inhibitory activities of angiotensin converting enzyme and bradykinin decomposing enzyme, and are useful as antihypertensive agents.

Chromanyl glycines

Useful intermediates for the preparation of hypotensives and inhibitors of angiotensin converting enzymes are L-alanyl-N-(indan-2-yl)glycine, its lower alkyl esters and the salts thereof.

L-Alanyl-N-(indan-2-yl)glycine, its esters and salts thereof

Novel peptide derivatives, inclusive of salts thereof, of the formula ##STR1## wherein A represents monocyclic or bicyclic hydrocarbon group, R.sup.1 and R.sup.3 are independently hydrogen, C.sub.1-4 alkyl or phenyl-C.sub.1-4 alkyl, and R.sup.2, R.sup.4 and R.sup.5 are independently hydrogen or C.sub.1-4 alkyl, have inhibitory activities of angiotensin converting enzyme and bradykinin decomposing enzyme, and are useful as antihypertensive agents.

Peptide derivatives, their production and use

Novel 1,2-dihydronaphthalene derivatives of the formula ##STR1## wherein A is a di-lower alkylamino group or a 5- to 7-membered cyclic amino group which may contain one oxygen atom and n is 2 or 3, and its salts have excellent pharmacological activities such as vasodilator, hypotensive and cerebral blood flow increasing actions.

Piperazine containing dihydronaphthalene derivatives and compositions

Novel 1,2-dihydronaphthalene derivatives of the formula ##STR1## wherein R.sup.1 and R.sup.2, independently of each other, are hydrogen, nitro, amino, halogen, or hydroxyl which may be protected, and R.sup.3 is a piperazinyl or morpholino group which may be substituted by lower alkyl, aralkyl, carboxylic acid-derived acyl, lower alkoxycarbonyl-lower alkyl or cycloaminocarbonyl-lower alkyl, and its salts have excellent pharmacological activities such as vasodilator and cerebral blood flow increasing activities.

1,2-Dihydronaphthalene derivatives and pharmaceutical composition

New isochroman derivatives which may be represented by general formula [I] ##STR1## wherein R.sup.1 is hydrogen atom, a lower alkoxy group or hydroxyl group and R.sup.2 is a lower alkoxy group or hydroxyl group; R.sup.1 and R.sup.2 may also be, connecting with each other, alkylenedioxy group; R.sup.3 is a hydrogen atom, a lower alkyl or aralkyl group and R.sup.4 is a lower alkyl or aralkyl group; R.sup.3 and R.sup.4 may also be groups which, taken together with the adjacent nitrogen atom, form a cyclic amino group; n means 1 or 2, and pharmacologically acceptable salt thereof have antidepressant, analgesic, diuretic, anti-inflammatory, muscle relaxing, vasodilator, hypotensive and other pharmacologic activities for mammals.

Isochroman derivatives

Novel compounds of the formula ##STR1## wherein R.sup.1 is lower alkyl, R.sup.2 is hydrogen, lower alkyl or lower alkenyl, R.sup.3 is hydrogen, lower alkyl, lower alkoxy or halogen and Y is lower alkylene.

Growing community of inventors

Kawanishi, Japan

Yoshikazu Oka