Banyu Pharmaceutical Co. Ltd

Yoshikazu Nagae

Yoshio Ogino

Akio Kanatani

Takehiro Fukami

Norikazu Otake

Minoru Moriya

Kenji Matsuda

Makoto Ishikawa

Teruyuki Nishimura

Katsumasa Nonoshita

Daisuke Tsukahara

Fumiko Sakai

Keisuke Arakawa

Hiroshi Nakashima

The present invention relates to compounds of Formula (I) wherein A, B and C are independently methine, said methine being optionally substituted; D is nitrogen; T, U, V and W are independently methine or nitrogen, said methine being optionally substituted and least two of T, U, V and W are said methine groups; X is &#x2014;N(SOR)&#x2014;, N(COR)&#x2014; or &#x2014;CO&#x2014;; Y is C(R)(R)&#x2014;, &#x2014;O&#x2014; or &#x2014;N(R) and a pharmaceutically acceptable salt, ester or N-oxide derivative thereof.

Benzimidazole derivatives

A glucokinase activator is provided; and a remedy and/or a preventive for diabetes, or a remedy and/or a preventive for diabetes such as retinopathy, nephropathy, neurosis, ischemic cardiopathy, arteriosclerosis, and further a remedy and/or a preventive for obesity are provided. A glucokinase activator characterized by containing a 2-heteroaryl-substituted benzimidazole derivative of a general formula (I-0) or its pharmaceutically-acceptable salt: [in the formula, X represents a carbon atom or a nitrogen atom; (in the formula, X represents a carbon atom or a nitrogen atom); Rrepresents an aryl, etc.; Rrepresents a hydroxy, etc.; Rrepresents a &#x2014;Calkyl, etc.; Rrepresents a &#x2014;Calkyl, etc.; Xrepresents &#x2014;O&#x2014;, etc.; a indicates an integer of 1, 2 or 3; q indicates an integer of from 0 to 2; m indicates an integer of from 0 to 2].

2-heteroaryl-substituted benzimidazole derivative

The present invention relates to a compound of the formula (I): (wherein A,,and D are independently nitrogen or optionally substituted methine; E is nitrogen, methine or hydroxy substituted methine; n is 0 or 1; T, U, V and W are independently nitrogen or optionally substituted methine; X is &#x2014;N(SOR)&#x2014;, &#x2014;N(COR)&#x2014; or &#x2014;CO&#x2014;; Y is &#x2014;C(R)(R)&#x2014;, &#x2014;O&#x2014; or &#x2014;N(R)&#x2014;, provided that the compound (I) when E is nitrogen, n is 0, X is &#x2014;CO&#x2014;, and Y is &#x2014;O&#x2014; is excluded) and the like, which are useful as an agent for the treatment of various diseases related to NPY.

The present invention relates to novel benzimidazole derivatives which are useful as neuropeptide Y receptor antagonists.

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Tsukuba, Japan

Yoshikazu Nagae