Kyowa Hakko Kogyo Co., Ltd.

Kyowa Hakko Kogyo Kabushiki Kaisha

Yoshikazu Morishita

Isao Kawamoto

Yuzuru Matsuda

Kenji Shibata

Motoo Yamasaki

Keiichi Yano

Kazuo Yamaguchi

Eiji Tsukuda

Toshiyuki Suzawa

Shigeto Kitamura

Shigeru Chiba

Mayumi Yoshida

Takeo Tanaka

Tatsuhiro Ogawa

Mika Makino

Toshihide Ikemura

Chieko Bando

Hiroshi Sano

Yutaka Saito

Mitsuru Takahashi

Hiroshi Kase

Katsuhiko Ando

Koji Yamada

Tomoyuki Sano

Endothelin-antagonizing peptide

The invention relates to biologically pure cultures of Streptomyces sp. RE-701 (FERM BP-3624) and Streptomyces sp. RE-629 (FERM BP-4126) that produce endothelin antagonistic peptides.

Strains of streptomyces producing endothelin antagonistic peptides

Peptides represented by the following formula (I): ##STR1## wherein A represents Asn or Asp; B represents His or Lys; and E represents Ala or Ser;

Compounds comprising a linear .beta.1.fwdarw.6 glucan esterified by caproic acid, the number of D-glucose residues being from 7 to 40 and the number of caproic acid residues being from 2 to 30, may be be obtained by fermentation of a microorganism of the genus Aureobasidium. These compounds are designated HS-142-1. Preferred microorganism is Aureobasidium pullulans var. melanigenum KAC-2383 (FERM-BP 2407). The compounds of the present invention exhibit excellent antagonistic activity to ANP and are capable of inhibiting the bonding of ANP to ANP receptors.

HS-142-1 compounds

Growing community of inventors

Machida, Japan

Yoshikazu Morishita