Kyowa Hakko Kogyo Co., Ltd.

Yoshikazu Miwa

Fumio Suzuki

Hiroaki Hayashi

Akio Ishii

Shunji Ichikawa

Ichiro Miki

Takeshi Kuroda

Kenji Ohmori

Katsuichi Shuto

Shigeto Kitamura

Haruhiko Manabe

Hiroshi Nakajima

Thienoimidazoppyridone derivatives

Quinoline derivative having serotonin-3 receptor antagonizing activity

There is disclosed a heterocyclic compound represented by general formula: ##STR1## wherein R.sup.1 represents hydrogen, lower alkyl or aryl; R.sup.2 represents hydrogen, hydroxyl or lower alkyl; A represents CH or N; X represents --O-- or --NH--; R.sup.3 represents hydrogen, hydroxyl or lower alkyl; R.sup.4 represents lower alkyl; represents 0 or 1, or a pharmaceutically acceptable salt thereof.

Certain 2-oxo-quinoline carboxylates or corresponding carboxamides

Disclosed is a thienopyridine derivative represented by formula (I): ##STR1## wherein one of A and B represents --S-- and the other represents --CH.dbd.; R represents hydrogen or lower alkyl, and Z represents pyridyl; or a pharmaceutically acceptable salt thereof. The thienopyridine derivative is useful as an immunoregulator and for the prevention and treatment of osteoporosis.

Thienopyridine derivatives

Disclosed is a thienopyridine derivative represented by formula (I): ##STR1## wherein one of A and B represents --S-- and the other represents --CH.dbd.; X represents --O-- or --NH--; R.sup.1 represents hydrogen or lower alkyl; R.sup.2 represents lower alkyl; and n represents 0 or 1; or a pharmaceutically acceptable salt thereof.

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Shizuoka, Japan

Yoshikazu Miwa