Senju Pharmaceutical Co., Ltd.

A. H. Robins Company, Incorporated

Yoshikazu Kuribayashi

Takahiro Ogawa

Akira Ohtori

Yujiro Yamamoto

Kazumichi Ushio

This invention relates to a locally administrable therapeutic composition for inflammatory disease which is characterized by comprising benzoylphenylacetic acid of the formula ##STR1## (wherein R is a hydrogen or halogen atom), or a salt thereof, or the hydrate of said acid or salt, as active ingredient. An ophthalmic composition according to the invention can treat effectively inflammatory eye disease by topical application, is not an irritant to the eye, and has a superior effect to conventional drugs of the same or similar type. The aqueous composition prepared in accordance with this invention has excellent stability and can be used advantageously as a nasal or otic composition as well as an ophthalmic one in the treatment of inflammatory otic or nasal disease.

Locally administrable therapeutic composition for inflammatory disease

An ocular antihypertensive composition for topical use which contains an effective amount of a compound represented by the formula ##STR1## or a salt thereof having, in low concentrations, intraocular pressure lowering activity in mammals, low toxicity and no influence on the pupil size and, therefore, is useful as a therapeutic agent for glaucoma, for instance. Furthermore, since the compound is effective in low concentrations, the possibility of tolerance development is considered to be scarce.

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Kobe, Japan

Yoshikazu Kuribayashi