Tokyo University of Agriculture and Technology

Tms Company LLC

Tokyo University of Agriculture and Technology Tlo Co., Ltd.

Yoshikazu Kitano

Keiji Hasumi

Keiko Hasegawa

Hideo Ohishi

Haruki Koide

Ritsuko Narasaki

Eriko Suzuki

Yuuichi Nishimura

Naoko Nishimura

Kohta Tsujihara

The invention provides a chroman derivative represented by the following Formula (I) that enables the production of an SMTP compound having a desired structure: 

Chroman derivative

A triprenyl phenol compound represented by the following formula (II) and (III) and having a thrombolysis-enhancing activity, and an efficient method for producing the triprenyl phenol compound. In formula (II) and (III), Rrepresents an aromatic group having as a substituent or as a part of a substituent at least one member selected from the group consisting of a carboxyl group, a hydroxyl group, a sulfonic acid group and a secondary amino group, or an aromatic group which comprises a secondary amino group and may comprise nitrogen; Rin the general formula (III) represents an aromatic amino acid residue represented by the general formula (III-1) below; X represents &#x2014;CHY&#x2014;(CH)Z; and Y and Z are respectively &#x2014;H or &#x2014;OH or together form a single bond: (III-1) wherein Rrepresents a hydroxyl group which may be present or absent; and n represents an integer of 0 or 1. 

Triprenyl phenol compound, process for production of triprenyl phenol compound, and thrombolysis enhancer

The present invention provides a triprenyl phenol compound represented by the following formula (II) and (III) and having a thrombolysis-enhancing activity, and an efficient method for producing the triprenyl phenol compound. In formula (II) and (III), Rrepresents an aromatic group having as a substituent or as a part of a substituent at least one member selected from the group consisting of a carboxyl group, a hydroxyl group, a sulfonic acid group and a secondary amino group, or an aromatic group which comprises a secondary amino group and may comprise nitrogen; Rin the general formula (III) represents an aromatic amino acid residue represented by the general formula (III-1) below; X represents &#x2014;CHY&#x2014;(CH)Z; and Y and Z are respectively &#x2014;H or &#x2014;OH or together form a single bond: (III-1) wherein Rrepresents a hydroxyl group which may be present or absent; and n represents an integer of 0 or 1. 

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Fuchu, Japan

Yoshikazu Kitano