Fujisawa Pharmaceutical Company, Ltd.

Astellas Pharma Gmbh

Green Tech Co., Ltd.

Toyo Aluminium Kabushiki Kaisha

Taiheiyo Cement Corporation

The Doshisha

National Center for Geriatrics and Gerontology

Sun Top Techno Co., Ltd.

Yoshikazu Inoue

Hisashi Takasugi

Takao Takaya

Masayoshi Murata

Yousuke Katsura

Tetsuo Tomishi

Hachiro Sugimoto

Nobuyoshi Yasuda

Atsushi Kuno

Kumi Yamasaki

Rie Tokizane

Yuki Sawada

Hideaki Yamanaka

Shigeki Satoh

Fumiyuki Shirai

Naoki Ishibashi

Kazunori Kamijo

Yoshiteru Eikyu

Hiroaki Mizuno

Yasuharu Urano

Koichiro Mukoyoshi

Michiaki Okuda

Shinichi Nakayama

Yuki Fujita

Yoko Sakata

Kenji Miyai

Kouichi Suzuki

Atsushi Akahane

Shigetaka Nishino

Takeshi Fujimura

Katsuyuki Ishikawa

Masaaki Toyama

Toru Ezaki

Takahiro Yamakawa

Kohei Takenaka

Akihiko Ikeya

Masatoshi Minagawa

Tetsuo Ota

Masako Kataoka

Yasuo Ihara

Tomohiro Miyasaka

Yoshiyuki Soeda

Yuki Shinzaki

Yohei Oe

Akihiko Takashima

A tau aggregation inhibitor can sufficiently inhibit a tau protein from aggregating in cells. The inhibitor includes a 4-substituted catechol structure compound, having, at position 4 of its catechol ring, an electron-donating substituent R other than a hydrocarbon group, or a salt thereof. The 4-substituted catechol structure compound is preferably 4-aminocatechol or 1,2,4-benzenetriol. Examples of tauopathies to which this inhibitor is applicable include AD, Down's syndrome, frontotemporal dementia, cotricobasal degeneration (CBD) and progressive supranuclear palsy (PSP).

Tau aggregation inhibitor

Provided is a novel therapeutic means for Alzheimer's disease. In particular, provided is a compound represented by the following general formula (I): ora salt thereof.

Pyrazole derivative

The invention provides a metallic pigment composition capable of preventing gelation of a UV metallic ink or a UV metallic coating material containing an ultraviolet-curable resin and providing good metallic effect and the stability with lapse of time and a UV metallic ink composition and a UV metallic coating material composition using it. The metallic pigment composition contains metal flakes and a nitrocellulose as essential components and the nitrocellulose is contained at a ratio in a range of 0.1 to 12 parts by mass to the metal flakes 100 parts by mass. The UV metallic ink and a UV metallic coating material are provided by adding the metallic pigment composition. The surfaces of the metal flakes are preferable to be coated with a phosphorus compound.

Metallic pigment composition and UV metallic ink composition or UV metallic coating composition using the same

Compounds having the formula (I): wherein

HDAC inhibitor

A compound having the formula (I): wherein

A running type road surface shape measuring apparatus for measuring the unevenness and grade of road surface in the longitudinal and transverse directions during running of vehicle comprises a vehicle body ( ), on which two running wheels ( ) and one measuring wheel ( ) are supported rotatably in series, said measuring wheels ( ) is located movably in the upward and downward direction between said two running wheels ( ), and an ancillary wheel ( ) is rotatably mounted on said body ( ) in parallel to said measuring wheel ( ). The measuring wheel ( ) is provided with a displacement measuring sensor ( ) for measuring a displacement in upward and downward directions of said measuring wheel ( ) and a distance measuring encoder ( ) for measuring a moving distance of said measuring wheel ( ), and said vehicle body ( ) is provided with an angle measuring sensor ( ) for measuring a grade of road surface.

Running type road surface shape measuring apparatus

Guanidine derivatives

In a piezoelectric transformer device (,), a plurality of inner electrodes are stacked on each other on the left side. These inner electrodes are alternately connected to each other through interlevel connection conductors to constitute two inner electrode groups. A secondary output electrode in the form of a mesh is formed near the end portion of the device (,) on the right side. Only primary input electrodes (,) connected to the two inner electrode groups, a secondary output electrode (,), and the lead electrode of the secondary output electrode in the form of a mesh are exposed on the same surface of the device.

Piezoelectric transformer device

Benzoylguanidine derivatives as medicaments

Guanidine derivatives as inhibitors of Na.sup.+ /H.sup.+  exchange in

Thiazole compounds of formula ##STR1## are provided which have antiulcer activity and H.sub.2 -receptor antagonism, wherein R.sup.2 is lower alkyl or lower alkoxy(lower)alkyl, R.sup.3 is hydrogen, A is methylene and R.sup.1 is lower alkyl.

H.sub.2 -receptor antagonist thiazoles

Furylthiazoles and their use as H.sub.2 - receptor antagonists and

A compound of the formula: ##STR1## wherein R.sup.1 is amino, acylamino, cyclo(lower)alkenylamino having amino and oxo, imido, triazolylamino, benzoisothiazolylamino, wherein each of said heterocyclicamino groups may be substituted by one or more substituent(s) selected from the group consisting of lower alkyl, amino and oxo, 2-cyano-3-lower alkylguanidino, 2-acyl-3-lower alkylguanidino, 2-acylguanidino, (1-lower alkylamino-2-nitrovinyl)amino, hydroxy, halogen, cyano, acyl, benzimidazolylthio, triazolyl substituted with amino, or a group of the formula: ##STR2## in which R.sup.4 is hydrogen, cyano, or acyl, and

Thiazole derivatives, processes for the preparation thereof and

Growing community of inventors

Amagasaki, Japan

Yoshikazu Inoue