Daiichi Pharmaceutical Co., Ltd.

Yoshikazu Ikeda

Makoto Yoshihama

Hidetoshi Takahashi

Shin Nomoto

Kiyoshi Isono

Kousaku Takahashi

Ken-ichi Kimura

Shinobu Kagami

Rolf Wolfgang Hartmann

Masamichi Nakakoshi

Masayuki Okue

Shin'ichi Shimada

Ken'ichi Kimura

Junji Nakamura

Makoto Ubutaka

Takeko Takada

Bertil Wachall

Makoto Ubukata

Antibiotics RK-1061s having a novel chemical structure and a method of production thereof. They have a structural formula represented by general formula(I) wherein A represents Ror RCH(OR)CH. Rrepresents 3-methylglutaric acid residue and Rrepresents a sulfate group or a hydrogen atom. The process comprises culturing a ray fungus belonging to the genusand isolating RK-1061s from the culture.sp. SN-1061Ms (FERM BP-5800) is capable of stably producing RK-1061 at a high productivity.

Antibiotics RK-1061 and process for preparing the same

Benzofuran derivatives

Dihydronaphthalene compounds have excellent 17&agr;-hydroxylase/C -lyase inhibiting activity, thromboxan A synthesis inhibiting activity, and aromatase inhibiting activity and are thereby are useful as preventive and/or therapeutic agents for various male sex hormone- and female sex hormone-dependent diseases such as prostate cancer, prostatomegaly, masculinization, breast cancer, mastopathy, uterine cancer, endometriosis, and ovarian cancer, as well as myocardial infarction, angina pectoris, and bronchial asthma.

Dihydronaphthalene compounds

Antibiotics RK-1061s having a novel chemical structure and a method of production thereof. They have a structural formula represented by general formula(I) wherein A represents R or R CH(OR )CH . R represents 3-methylglutaric acid residue and R represents a sulfate group or a hydrogen atom. The process comprises culturing a ray fungus belonging to the genus Streptomyces and isolating RK-1061s from the culture. Streptomyces sp. SN-1061Ms (FERM BP-5800) is capable of stably producing RK-1061 at a high productivity.

Growing community of inventors

Shimotsuga-gun, Japan

Yoshikazu Ikeda