Matsushita Electric Industrial Co., Ltd.

Ono Pharmaceutical Co., Ltd.

Matsushita Electrical Industrial Co., Ltd.

Matushita Electric Industrial Co., Ltd.

Yoshikazu Goto

Yukio Nishino

Kuniko Nakata

Takashi Ishida

Isao Satoh

Shunji Ohara

Benichi Miyazaki

Shigeto Ueno

Norikatsu Yoshida

Ichiro Kawamura

Ryoichi Imanaka

Hitoshi Higaki

Ichirou Kawamura

Akira Kurozuka

Hironori Okazawa

Hiroyuki Takeuchi

Soichiro Mima

Eiichi Hanakawa

Kimiaki Sano

Kenji Sasaki

Kousuke Tani

Toru Sato

Tohru Kambe

Masayoshi Kato

Yoshihiko Sugiyama

Shinsaku Yamane

Toshihide Watanabe

Seiji Ogawa

Isao Sato

Takashi Konemura

Isamu Sugimoto

Shoji Nojima

Kazumi Moriyuki

Teruyuki Takizawa

Yoshihiro Mushika

Toshiyuki Shimada

Hitoshi Fujii

Satoshi Kikuya

Yoshiteru Namoto

A compound represented by general formula (I) (in the formula, all symbols are as described in the description) or a salt thereof has a potent nerve-protecting and/or -repairing activity, and therefore can be used as a therapeutic agent for neuropathy (e.g., chronic inflammatory demyelinating polyneuropathy, Guillain-Barre syndrome, periarteritis nodosa, allergic vasculitis, diabetic peripheral neuropathy, entrapment neuropathy, peripheral neuropathy associated with the administration of a chemotherapeutic drug, or peripheral neuropathy associated with Charcot-Marie-Tooth disease).

Benzene derivative

A compound represented by general formula (I) (in the formula, all symbols are as described in the description) or a salt thereof has a potent nerve-protecting and/or -repairing activity, and therefore can be used as a therapeutic agent for neuropathy (e.g., chronic inflammatory demyelinating polyneuropathy, Guillain-Barre syndrome, periarteritis nodosa, allergic vasculitis, diabetic peripheral neuropathy, entrapment neuropathy, peripheral neuropathy associated with the administration of a chemotherapeutic drug, or peripheral neuropathy associated with Charcot-Marie-Tooth disease). 

Provided is an EP2 agonist having excellent safety. A compound represented by general formula (I) (wherein all symbols are as defined in the description), a salt or N-oxide of the compound, or a solvate or prodrug of the compound or the salt or N-oxide has an EP2 agonist activity and is highly safe, and is therefore useful as a medicine, particularly a therapeutic agent for diseases associated with EP2 receptors, such as immune diseases, allergic diseases, neuronal death, dysmenorrhea, premature birth, miscarriage, baldness, ocular diseases, erectile dysfunction, arthritis, lung injury, pulmonary fibrosis, pulmonary emphysema, bronchitis, chronic obstructive pulmonary disease, bone diseases and cartilage injury.

Compound having EP2 agonist activity

A compound represented by general formula (I) wherein all symbols are as defined in the specification, a salt or N-oxide of the compound, or a solvate or prodrug of the compound or the salt or N-oxide has a selective EP2 agonist activity and is highly safe, and is therefore useful as a drug, especially as a therapeutic agent for EP2 receptor-related diseases including immune diseases, allergic diseases, neuronal death, dysmenorrhea, premature birth, miscarriage, baldness, ocular diseases, erectile dysfunction, arthritis, lung injury, pulmonary fibrosis, pulmonary emphysema, bronchitis, chronic obstructive pulmonary disease, bone diseases, cartilage injury and others. 

Compound having selective EP2 agonist activity

A cartridge for housing a recording medium therein. The cartridge includes a cartridge body configured such that a signal recording apparatus can record a signal onto the recording medium when the cartridge is loaded in the signal recording apparatus. The cartridge also includes an opening in the cartridge body for removing the recording medium from the cartridge body, and a cover covering the opening. An indicator on the cartridge body indicates whether the cover has ever been opened or removed from the cartridge body.

Recording medium cartridge and signal recording apparatus

Information recording method, information recording/reproducing apparatus, and information recording medium

A disc cartridge includes a disc holder for supporting a recording medium. The disc holder includes a grip. A case defines a housing portion for receiving the disc holder and the recording medium. The case allows the disc holder with the recording medium to be inserted into and removed from the housing portion via an opening. The disk holder also includes a lock for securing the disc holder to the case at a position. The grip has side portions tapering from a bottom end to a top end of the grip, the top end of the grip having a smaller width than the bottom end of the grip. A cut of the upper case and a cut of the lower case are shaped to correspond with the taper of the side portions of the grip thereby facilitating smooth engagement of the grip and the cuts.

Disc cartridge

A disc cartridge adaptor for housing a information storage disc and a disc holder. The disc cartridge adaptor includes: a case body including a housing portion for rotatably housing the disc, and an opening communicating with the housing portion for allowing insertion and removal of the disc holder and the disc. A lid is pivotably supported by the case body. The housing portion is able to house the disc together with the disc holder or without the disc holder. The lid includes a positioning member movable between a first position and a second position with respect to the lid. The positioning member is in the first position restricting the position of the disc within a predetermined range when the disc is housed in the housing portion without the disc holder, and retreats to the second position when the disc holder is housed in the housing portion.

Disc cartridge adaptor

A disc cartridge in accordance with the present invention includes a disc holder for supporting a disc-shaped recording medium; and a case for receiving the disc holder and the recording medium. The disc holder includes at least one finger-shaped flexible member that extends from a side face of the disc holder and bends in the plane substantially parallel with top and bottom portions of the disc holder. The case further includes an opening and a member for engaging with the flexible member to secure the disc holder; and means for preventing an easy touch of a human finger on the flexible member to protect the disc holder from being easily released. Once the disc holder is housed in the case, part of the disc holder blocks the opening of the case.

Disc cartridge including a disc holder with a flexible member

A disc case having a case main unit including an accommodation chamber for rotatably accommodating a disc having a signal recording surface on at least one side of the disc, support member access openings provided in the top and bottom walls of the accommodation chamber so that a chucking member can apply an external pressure to the disc, a head access opening formed in the top or bottom wall of the accommodation chamber and tangent to the side wall surface of the accommodation chamber so that a read/write head can read and/or record signals on the signal recording surface of the disc, and a concave portion formed in an area extending from the side wall surface at the head access opening to the front fringe portion of the case main unit and concave with respect to the top or bottom surface of the main unit of the case. The disc case also includes a shutter installed on the case main unit to cover the support member access openings, the head access opening and the concave portion when the shutter is closed. The shutter opens to expose the support member access openings and the head access opening by sliding in at least one direction from the covered position along the front fringe portion of the case main unit. A shielding portion provided on the case main unit shields all or a part of the passages communicating with the accommodation chamber even when the shutter is closed.

Disc case

A disk cartridge of the present invention comprises a case body ( ) having a disk-storage portion and an opening/closing cover ( ) having a pair of disk holding members ( ) that hold a disk ( ) in its inplane direction. The accommodated disk ( ) is loaded together with the opening/closing cover ( ) into an adapter having compatibility with a large disk cartridge. Thus, information can be, for example, reproduced from the disk ( ) in a drive unit designed for a large disk cartridge via the adapter. Moreover, a series of operations can be conducted without touching the disk directly.

Disk cartridge and adapter

Growing community of inventors

Hirakata, Japan

Yoshikazu Goto