Dai Nippon Printing Co., Ltd.

Other

Asahi Kasei Medical Co., Ltd.

Tokyo Women's Medical University

Cellseed, Inc.

Amersham Biosciences Kk

Tokyo Woman's Medical University

Yoshikatsu Akiyama

Teruo Okano

Tatsuya Shimizu

Masayuki Yamato

Masanao Watanabe

Kimihiro Yoshizako

Ichiro Koguma

Hiroki Shigematsu

Kazuo Okuyama

Kenichi Nagase

Katsuhiko Ueno

Kazunori Kataoka

Hiroya Watanabe

Yukio Hasegawa

Kenichi Hagiwara

Keisuke Ashiba

Provided is a temperature responsive adsorbent prepared by immobilizing a copolymer containing at least N-isopropylacrylamide to a base material surface. The copolymer has at least a strong cation exchange group. In addition, the copolymer contains the strong cation exchange group in an amount of 0.01 to 5 mol % relative to N-isopropylacrylamide in terms of monomer.

Temperature responsive adsorbent having a strong cation exchange group and method for producing the same

This invention is intended to provide cell aggregates that can reproduce functions of the myocardium, such as the function of beating, and thus are available for myocardial regenerative therapy, and to provide a cell culture support for producing the same. According to this invention, a cell culture support for forming string-shaped cardiomyocyte aggregates, which has a substrate portion having one surface on which at least one linear cell-adherent region is formed is provided.

Cell culture support for forming string-shaped cardiomyocyte aggregates

Methods and reagents are described for myocardial regenerative therapy using cardiomyocytes that are cultured ex vivo to have a controlled orientation of beating. This is achieved by growing the cardiomyocytes on a culture support that is coated with a polymerizable liquid crystal which is oriented so as to be in a liquid crystal phase state prior to curing with ionizing radiation or ultraviolet rays.

Cardiomyocyte culture support

An object of the present invention is to provide a cell culture support making the detachment of a cell sheet easy as well as enabling the formation of a uniform cell sheet. The present invention relates to a method for manufacturing a cell culture support having a temperature responsive polymer immobilized onto the surface thereof via covalent bonding, the method including a coating step in which a composition including a monomer that can form the polymer by polymerization by radiation irradiation, an organic solvent and, in some cases, a prepolymer formed by polymerization of the monomer is coated onto the substrate having a surface containing a material which can be covalently bonded to the temperature responsive polymer by radiation irradiation to form a film on the surface of the substrate, a radiation irradiation step in which a polymerization reaction and a binding reaction between the substrate surface and the temperature responsive polymer are allowed to proceed by irradiating radiation to the film, and a drying step to dry the film.

Cell culture support and manufacture thereof

A temperature-responsive polymer and polymer material which has ester bond(s) and/or acid amide bond(s) respectively at one or more sites in the side chain and can be arbitrarily controlled by varying the side chain is provided.

Temperature-responsive polymer compound and process for producing the same

A novel method for separating a target substance, for example, metal ion, drug or biological component is provided. According to the method, the surface of a packing undergoes a chemical or physical environmental change under a physical stimulus so that the interaction of a substance interacting with the target substance is reversibly changed in an aqueous solution, thus effecting separation.

Separatory material with the use of stimulus-responsive polymer and separation method by using the separatory material

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Tokyo, Japan

Yoshikatsu Akiyama