Asahi Kasei Chemicals Corporation

Asahi Kasei Kabushiki Kaisha

Asahi Kasei Kogyo Kabushiki Kaisha

Yoshihito Yaginuma

Naoya Yoshida

Nobuyoshi Mochihara

Rika Matsumoto

Akihiro Sakamoto

Kouichirou Enatsu

Masaaki Endo

Kazuhiro Obae

Naoaki Yamasaki

Etsuo Kamada

Ichiro Ibuki

Yoshinaga Tamura

Ichirou Ibuki

Hiroto Miyamoto

Yurika Tanaka

Tetsuya Ootani

Mitsuyo Akimoto

Yasushi Kawamura

Yuka Itou

Kouichi Noda

Sueo Nagatomo

Provided is a process for producing spherical base granules comprising a easily water-soluble drug and suited for film coating by spraying a layering liquid over pharmaceutically inert spherical core particles, thereby coating the particles with a layer comprising the easily water-soluble drug, wherein (1) the spherical core particles have a microcrystalline cellulose content of 30 mass % or greater and a water absorbing capacity of 0.5 cm/g or greater; and (2) the layering liquid is an aqueous solution comprising at least the easily water-soluble drug and a low water-soluble saccharide.

Process for producing spherical base granule comprising easily water-soluble drug

Spherical base granules comprising a hardly water-soluble drug and suited for film coating thereon are produced by layering spherical core particles with a drug-containing layering liquid comprising both micronized microcrystalline cellulose and an emulsifier therein and therefore having improved suspension stability.

Method for producing spherical base granules comprising hardly water-soluble drug

Disclosed is a solid preparation which comprises at least one active ingredient and at least one dissolution-controlling base substance and can be formed by compression molding, wherein the dissolution-controlling base substance contains 5.0 to 99.9% by weight (inclusive) of a modified starch having a moisture retaining capacity of 400% or more and a gel indentation load of 200 g or more, containing a water-soluble ingredient in an amount of 40 to 95% by weight, having particles passing through a 75 &#x3bc;m-mesh sieve in the proportion of 90% by weight or more and particles passing through a 32 &#x3bc;m-mesh sieve in the proportion of 20% by weight or more, and having an average particle diameter of not smaller than 20 &#x3bc;m and smaller than 50 &#x3bc;m.

Controlled release solid preparation

Disclosed is an aqueous composition containing (a) an ethyl acrylate/methyl methacrylate copolymer or a plasticized vinyl accetate polymer, (b) an ethyl cellulose, (c) a water soluble additive for pharmaceutical products, (d) titanium oxide and (c) water. The solid content mass ratio among the components (a), (b), (c) and (d), namely a:b:c:d is 100:(5-50):(1-50):(0.5-10), and the solid content concentration in the aqueous composition is 0.5-40% by mass.

Aqueous composition

A process for producing a granule-containing tablet comprising mixing more than 25 mass % to 89 mass % or less of crystalline cellulose exhibiting a tensile displacement at break of 25 to 80 &#x3bc;m and a relative fluidity index of 2.15 to 2.80 at a maximum compaction stress of 15 kPa, 10 to 70 mass % of spherical granules, and 20 mass % or less of a disintegrant, and then compressing the obtained mixture.

Process for production of crystalline cellulose and tablets containing granules

Disclosed is a cellooligosaccharide composition comprising, as the main ingredient, at least one cellooligosaccharide selected from the group consisting of cellobiose, cellotriose, cellotetraose, cellopentaose and cellohexaose, which is in the powdery form having an average L/D value of 3.0 or lower, a bulk density of 0.80 g/mL or lower and an angle of repose of 60&#xb0; or lower.

Cellooligosaccharide-containing composition

An object of the present invention is to provide an aqueous film coating solution, and the like, which has good acid resistance and sustained release properties as well as the flexibility suitable for the tablet compression force and are highly productive and cost efficient. The aqueous film coating solution of the present invention comprises an ethyl acrylate/methyl methacrylate copolymer dispersion, a methacrylic acid copolymer LD, a plasticizer, titanium oxide and water, wherein the solid mass ratio of the ethyl acrylate/methyl methacrylate copolymer dispersion, the methacrylic acid copolymer LD, the plasticizer and the titanium oxide is 100:(40 to 100):(5 to 50):(5 to 30) and the solid content thereof is 5 to 20 mass %.

Aqueous film coating solution, film coated granule and tablet using the same

A material is provided to give food products sufficient viscosity and stability (heat resistance, stable suspension, etc.). The material is produced from an inexpensive raw material by an economical process. Further, a novel gel containing cellulose as the main component is also provided. The present invention provides a fine fibrous water-dispersible cellulose derived from plant cell walls. For the production, a raw material having specific properties is used, and size reduction is carried out stepwise thereto. The water-dispersible cellulose can also be made into a dry composition by compounding with a water-soluble polymer or the like. This dry composition forms a gel when combined with a polysaccharide such as glucomannan or the like. The gel excels in heat-resistance and shape-retention and can be used to produce to novel food products.

Water-dispersible cellulose and process for producing the same

A fine-cellulose-containing complex comprising 60 to 80 wt % of fine cellulose, 2 to 12 wt % of locust bean gum, 0.5 to 8 wt % of xanthan gum and 0 to 37.5 wt % of a hydrophilic material(s), the complex being a powder wherein the average particle size of particles formed by mild dispersion of the complex in water at 85&#xb0; C. is 60 &#x3bc;m or less, the proportion of particles with a particle size of 100 &#x3bc;m or more among the formed particles is 30 vol % or less based on the total volume of the formed particles, and a colloid fraction in the case of vigorous dispersion of the complex in water at 25&#xb0; C. is 30% or less.

Composite containing fine cellulose

A cellulose-containing composite contains 20-99% by weight of a fine cellulose and 1-80% by weight of at least one low-viscosity water-soluble dietary fiber selected from the group consisting of 1) a hydrolyzed gallactomannan, 2) an indigestible dextrin and 3) a mixture of a polydextrose and xanthan gum and/or gellan gum, wherein the total amount of gellan gum and xanthan gum is 0.1% by weight or more but less than 3% by weight of the composite, in which composite the average particle size of the fine cellulose is 30 &mgr;m or less when the composite is dispersed in water.

Cellulose-containing composite

Disclosed is an excipient comprising white powdery microcrystalline cellulose having an average degree of polymerization of from 100 to 375 and an acetic acid holding capacity of 280% or more, and having a specific compression characteristic satisfying an equality of formula (1): ##EQU1## wherein a is from 0.85 to 0.90, b is from 0.05 to 0.10, P represents the compression pressure (kgf/cm.sup.2) applied to the microcrystalline cellulose, V.sub.o represents the apparent specific volume (cm.sup.3 /g) of the microcrystalline cellulose, and V.sub.p represents the specific volume (cm.sup.3 /g) of the microcrystalline cellulose at the compression pressure P. The excipient of the present invention exhibits not only high compactability but also high rate of disintegration. The excipient of the present invention can be advantageously obtained by heat-treating an aqueous dispersion of purified cellulose particles, which has a solids content of 40% or less by weight, at 100.degree. C. or more, followed by drying, or by subjecting an aqueous dispersion of purified cellulose particles having a solids content of 23% or less by weight to thin film-forming treatment and drying the resultant thin film.

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Tokyo, Japan

Yoshihito Yaginuma