Celldex Therapeutics Limited

Kolltan Pharmaceuticals, Inc.

Plexxikon Inc.

Yoshihisa Suzuki

Prabha N Ibrahim

Wayne Spevak

Jiazhong Zhang

Joseph Schlessinger

Chao Zhang

Guoxian Wu

Brian L West

Dean R Artis

Yong-Liang Zhu

Hanna Cho

Yaron R Hadari

Marika Nespi

Ryan Bremer

Shumeye Mamo

Gideon Bollag

Shenghua Shi

Klaus-Peter Hirth

Rebecca Zuckerman

Hongyao Zhu

Elizabeth M Mandel-Bausch

Gaston G Habets

James Tsai

Samuel J Gillette

Susanne Radke

Provided herein, in one aspect, are antibodies that immunospecifically bind to a human KIT antigen comprising the fourth and/or fifth extracellular Ig-like domains (that is, D4 and/or D5 domains), polynucleotides comprising nucleotide sequences encoding such antibodies, and expression vectors and host cells for producing such antibodies. The antibodies can inhibit KIT activity, such as ligand-induced receptor phosphorylation. Also provided herein are kits and pharmaceutical compositions comprising antibodies that specifically bind to a KIT antigen, as well as methods of treating or managing a KIT-mediated disorder or disease and methods of diagnosing a KIT-mediated disorder or disease using the antibodies described herein.

Anti-KIT antibodies and uses thereof

Methods of treating by administering anti-kit antibodies

Polynucleotides encoding anti-KIT antibodies

Anti-kit antibodies

Growing community of inventors

Hamden, CT, United States of America

Yoshihisa Suzuki