Nitto-denko Corporation

Hokuriku Seiyaku Co., Ltd.

Nitto Electric Industrial Co., Ltd.

Other

Teikoku Hormone Mfg. Co., Ltd.

Toa Eiyo Ltd.

Ikeda Mohando Company, Ltd.

Bio-i Co., Ltd.

Nakano, Yoshihisa

Yoshihisa Nakano

Saburo Otsuka

Mitsuhiko Hori

Hitoshi Akemi

Takashi Kinoshita

Yoshifumi Hosaka

Keiji Yamamoto

Kensuke Matsuoka

Kenjiro Minomi

Tetsuo Horiuchi

Yuichi Inoue

Kunio Tsukamoto

Mitsuru Tamada

Tetuo Horiuchi

Erina Kobayashi

Senji Unozawa

Sanae Fujiwara

Mitsuhiro Uenoyama

Toshinobu Tsuda

Yuichi Yoshida

To provide a pectin lyase and a gene for a pectin lyase which can be used in an enzyme preparation for processing plant tissue, and which possesses sufficient maceration activity even under highly acidic conditions. Isolation and purification of a pectin lyase and a gene for a pectin lyase having a molecular weight of 39,500 produced by anfilamentous fungus, and possessing a maceration activity and a pectin lyase activity. The pectin lyase has a specified amino acid sequence, an optimal pH of 3.5 for maceration activity, an optimal pH of 4.5 for pectin lyase activity, and deactivates with boiling treatment for 15 minutes at 121&#xb0; C. Sterilizing heat treatment are unnecessary, because the present invention possesses sufficient maceration activity at pH 3.0-4.0, and the resulting pectin lysate possesses a bactericidal activity and a potent antibacterial activity. It is possible to inexpensively mass produce food products which retain water-soluble components within the cell, because physical treatment such as stirring or beating is also unnecessary.

Pectin lyase, pectin lyase polynucleotide, enzyme preparation, and method for producing single cells of plant tissue

The present invention relates to a patch containing a substrate, a non-crosslinked adhesive layer (A) containing a drug laminated on one surface of the substrate and a crosslinked adhesive layer (B) laminated on the adhesive layer (A). According to the present invention, the percutaneous absorbability of the drug can be improved, and a patch free of problems such as adhesive residue and adhesive bleed can be provided.

Patch and production method thereof

A percutaneously absorptive preparation is provided, which preparation having a support and an adhesive layer having a release-controlling layer, which is formed at least on one side of the support, wherein the adhesive layer contains an adhesive and 0.5&#x2013;60 wt % of a drug except 1,2-ethanediol derivatives.

Percutaneously absorptive preparation

The present invention provides a percutaneous absorption preparation which comprises a skin contact base containing therein at least one active ingredient selected from the group consisting of biperiden, trihexyphenidyl and pharmacologically acceptable salts thereof in an amount of from 0.5 to 60% by weight. The percutaneous absorption preparation makes it possible to permit the percutaneous absorption of biperiden, trihexyphenidyl or pharmacologically acceptable salt thereof as an active ingredient so that the medicament can be used effectively and at the same time, pharmacological effects can be sustained long and administration can be carried out conveniently. In addition, the active ingredient contained in it can be maintained stably.

Percutaneous absorption preparation

A percutaneous absorption type preparation comprising a support and a plaster layer laminated thereon, which composes tulobuterol in a proportion of not less than 5 wt % in a dissolution state and an adhesive. The preparation of the present invention retains the active ingredient, tulobuterol, at a high concentration in a complete dissolution state in the plaster layer. Therefore, it is free of time-course changes in drug releasing property and adhesive property caused by precipitation of drug crystals with the lapse of time. The inventive preparation is superior in percutaneous absorption of the drug, particularly percutaneous absorption rate at the initial stage of the administration; shows superior duration of efficacy by maintaining effective blood concentration for a long time; and is associated with less changes with the lapse of time in adhesive property such as adhesion to the skin.

Percutaneous absorption type preparation

A percutaneous absorption preparation comprising a support and, formed on one side thereof, a plaster layer comprising a pressure-sensitive adhesive and tulobuterol in an amount not lower than its saturation solubility in the pressure-sensitive adhesive, the tulobuterol contained in the plaster layer consisting of dissolved tulobuterol and crystalline tulobuterol with the ratio of the content of the crystalline tulobuterol to that of the dissolved tulobuterol being from 0.1 to 10.

A percutaneous preparation of tulobuterol is disclosed, comprising a support having thereon a base layer comprising a pressure-sensitive adhesive containing tulobuterol, the pressure-sensitive adhesive comprising polyisobutylene. The preparation achieves persistent and effective administration of tulobuterol through the skin into the body.

Percutaneous preparation of tulobuterol

An acrylic oily gel bioadhesive material comprising a substrate having on one surface thereof a crosslinked gel layer formed by crosslinking a composition comprising an acrylate polymer comprising as a main component an alkyl (meth)acrylate having four or more carbon atoms in the alkyl moiety and a liquid ingredient compatible with said acrylate polymer.

Acrylic oily gel bioadhesive material and acrylic oily gel preparation

An estrogen-containing gel preparation is disclosed, which comprises a substrate having on one surface thereof a crosslinked gel layer formed by crosslinking a composition comprising the following ingredients (a) to (c), the weight ratio of the ingredient (b) to the ingredient (c) being from 1.0/0.25 to 1.0/2.0:

Estrogen-containing gel preparation

A percutaneous gel preparation is disclosed, which comprises a substrate having one surface thereof a crosslinked gel layer formed by crosslinking a composition comprising the following ingredients (a) to (c), the weight ratio of the ingredient (b) to the ingredient (c) being from 1.0/0.25 to 1.0/2.0:

Percutaneous gel preparation

An anti-inflammatory analgesic adhesive preparation is disclosed, comprising a flexible support having laminated thereon a pressure-sensitive adhesive material layer which contains a non-steroidal anti-inflammatory analgesic agent having salt form and an organic acid. This adhesive preparation has excellent percutaneous absorption properties.

Anti-inflammatory analgesic adhesive preparation

An anti-inflammatory analgesic adhesive preparation is disclosed, comprising a flexible support having laminated thereon a pressure-sensitive adhesive material layer which contains Diclofenac Sodium and an organic acid such as citric acid. This adhesive preparation has excellent percutaneous absorption properties.

Growing community of inventors

Osaka, Japan

Yoshihisa Nakano