Bizen Chemical Co., Ltd.

Harima Chemicals, Incorporated

Ulvac, Inc.

Denso Corporation

Sagami Chemical Research Center

Q.p. Corporation

Iwate Prefectural Government

Yoshihisa Misawa

Yoshio Shimizu

Yorishige Matsuba

Hiroshi Tabata

Masaaki Oda

Toshihiro Suzuki

Noriyuki Abe

Jun Fujii

Naomichi Bamba

Tadahiro Tsushima

Norimichi Saito

Kiyosi Kondo

Hideaki Kobayashi

Masashi Totokawa

Hisao Kondo

Masahiro Hayashi

Kazunaga Yazawa

Masayuki Ueda

Keisuke Uryu

Akira Yano

Katsuhisa Osako

Hideyuki Gotoh

Hideyuki Goto

Tetsuro Taira

Mitsumasa Mankura

Daisuke Sugimori

Hiroyuki Sakaguchi

Tetsuya Tsutsumi

Hidetoshi Yamada

Masashi Isozaki

Shiho Saito

Katsuhisa Oosako

Sayaka Yuki

Naomichi Baba

Hiroharu Nishigaki

The present invention provides a lipoxygenase that enables the highly efficient formation of an oxide of a highly unsaturated fatty acid or an oxide of a highly unsaturated fatty acid derivative from a highly unsaturated fatty acid or a highly unsaturated fatty acid derivative. The present invention provides a lipoxygenase that enables the highly efficient formation of 8-hydroxyeicosatetraenoic acid from arachidonic acid, the highly efficient formation of 8-hydroxyeicosapentaenoic acid from eicosapentaenoic acid, and the highly efficient formation of 10-hydroxy docosahexaenoic acid from docosahexaenoic acid. Specifically, the present invention provides a polynucleotide that comprises the nucleic acid sequence represented by SEQ ID NO: 1 and 3, or a homolog thereof, and a polypeptide that comprises the amino acid sequence represented by SEQ ID NO: 2 and 4, or a homolog thereof. Also provided is a composition that comprises a membrane protein of an organism belonging to the class Malacostraca and is for carrying out a lipoxygenase reaction.

Oxidation of highly unsaturated fatty acids with novel 8-lipoxygenase derived from Malacostraca

Provided is a method for producing an unsaturated fatty acid oxide (e.g. &#x3c9;3 fatty acid oxide) that is new and has more beneficial features compared to conventional technologies. This method uses a lipoxygenase-containing composition (e.g. a lipoxygenase-containing composition derived from beans) as a lipoxygenase enzyme, and also uses a freezing method with organic solvent extraction. The present invention makes it possible to produce an unsaturated fatty acid oxide (e.g. &#x3c9;3 fatty acid oxide) efficiently and at a low cost. The present invention also provides a pharmaceutical composition containing an &#x3c9;3 fatty acid oxide isolated and purified by this method as an active ingredient.

Method for producing omega 3 and omega 6 unsaturated fatty acid oxides

A method of chemically extending a carbon chain of an unsaturated fatty acid for conversion into a different unsaturated fatty acid has been reported. The present invention shortens reaction steps of conventional methods, and completes a carbon chain extending reaction in a shorter time. The present invention provides a method of extending a carbon chain of an unsaturated fatty acid by two carbons, comprising steps of four stages including a short-path conversion reaction of an unsaturated fatty chain obtained from an unsaturated fatty acid into a malonic ester derivative, and heating of the malonic ester derivative to reflux in a lower fatty acid solution. The method of the present invention can complete a carbon chain extending reaction in a shorter time.

Synthesis of long-chain unsaturated fatty acid by chemical reaction of carbon chain extension

A production method of highly unsaturated fatty acids with a high purity/high yield that compensates for shortcomings of conventional techniques is provided. A purification method of highly unsaturated fatty acids and/or derivatives thereof comprising (a) contacting and stirring first raw materials comprising the substances with a first silver salt aqueous solution to collect a first oil layer and a first aqueous layer; (b) separating the first aqueous layer into a second silver salt aqueous solution and the substances; and (c) contacting and stirring the first oil layer with the second silver salt aqueous solution for separation into an oil layer and an aqueous layer to obtain a second aqueous layer comprising the substances.

Production method of highly unsaturated fatty acid with high purity/high yield

The present invention provides a method of producing/purifying highly unsaturated fatty acids and/or derivatives thereof while suppressing deterioration of a silver salt aqueous solution, in production/purification of highly unsaturated fatty acids and/or derivatives thereof using the aqueous solution of silver salt. The present invention also contacts or mixes a mixture having a peroxide value (POV) of 10 or smaller with an aqueous solution of silver salt, in a method of purifying highly unsaturated fatty acids and/or derivatives thereof from a mixture comprising highly unsaturated fatty acids and/or derivatives thereof.

Production method of highly unsaturated fatty acid ethyl ester

A method of obtaining a polyunsaturated fatty acid derivative comprises contacting a mixture of fatty acid derivatives with a silver salt aqueous solution, and adjusting the free fatty acid content in the silver salt aqueous solution to 0.2 meq or less per gram of silver when repeatedly using the silver salt aqueous solution. A polyunsaturated fatty acid derivative having high purity and excellent quality can thus be economically obtained.

Method for obtaining polyunsaturated fatty acid derivatives

This invention provides a low-temperature sintering conductive paste for high density circuit printing which can form a fine circuit having good adhesive force, a smooth surface and low resistance when applied on a substrate and then baked; the conductive paste of the invention uses, as conductive media, in combination with metal fillers having an average particle diameter of 0.5 to 20 &#x3bc;m, ultrafine metal particles having an average particle diameter of not larger than 100 nm, which are set in the state that the surfaces thereof are coated with one compound or more having a group comprising a nitrogen, oxygen, or sulfur atom and capable of coordinate-bonding by a lone pair existing in the atom, as a group capable of coordinate-bonding to a metal element contained in the ultrafine metal particles, and are dispersed uniformly in a resin composition comprising a heat curable resin component, an organic acid anhydride or a derivative thereof or an organic acid, and one or more organic solvent; and thereby it enables low-temperature sintering of the ultrafine metal particles during a heat treatment at a low temperature.

Electroconductive metal paste and method for production thereof

To provide a method for producing a sensing film for gas sensors by sintering particles comprising a metal or a metal oxide on a substrate, where the sensing film for gas sensors having excellent sensor properties such as sensitivity and responsibility can be easily and simply formed. A nano-meter order particle (), a dispersant () for preventing aggregation of the particles (), and a scavenger () for trapping the dispersant () at the sintering are mixed in a solvent () to prepare a paste body (), and this paste body () is coated on a base material and fired, thereby forming a sensing film.

Production method of gas sensor

[Object] A fatty acid-related polyunsaturated compound can be selectively purified using an industrially operable successive method under moderate conditions. [Content] A highly purified fatty acid-related polyunsaturated compound is obtained by a process comprising steps of forming a complex with silver on account of the high degree of unsaturation of the fatty acid-related polyunsaturated compound, isolating the complex from other fats on account of the hydrophilicity of the complex and then applying dissociating procedures to the complex to obtain the fatty acid-related polyunsaturated compound as a target substance on account of the hydrophobicity of the fatty acid-related polyunsaturated compound. As to the procedures for dissociation, addition of a dissociating agent and reduction of silver are disclosed. As to the dissociating agent, various compounds which produce insoluble composition with silver other then water are disclosed. Furthermore, an apparatus appropriately used to carry out this method is also disclosed.

Method of purifying polyunsaturated aliphatic compounds

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Akaiwa, Japan

Yoshihisa Misawa