Daikin Industries, Ltd.

Kaneka Corporation

Yoshihiro Yamamoto

Tatsuya Ohtsuka

Yoshichika Kuroki

Nobuhiko Tsuda

Tetsuo Shimizu

Yasuhiko Sawada

Yoshinori Nanba

Yosuke Kishikawa

Akiyoshi Yamauchi

Yuzo Komatsu

Sumi Ishihara

Daisuke Karube

Shigeaki Yamazaki

Kenzou Takahashi

Akinori Yamamoto

Yuuki Suzuki

Yousuke Kishikawa

Hiroyuki Arima

Masahiro Higashi

Atsushi Suzuki

Takaya Yamada

Yoshiko Kuwajima

Tomoya Hidaka

Hisako Nakamura

Kotaro Hayashi

Kazuhiro Shimokawa

Akihiro Gotou

Akinari Sugiyama

Masakazu Kinoshita

Takuji Ishikawa

Kenji Yamaguchi

Masahiko Sameshima

Atsushi Maruo

Toshiharu Shimooka

Toru Yoshizawa

Yorisato Hisanaga

Kunitada Tanaka

Taro Kiguchi

Hiroyuki Iwai

Toshihiko Kawano

Takashi Hamamoto

A method for producing a cyclic carbonate represented by the following formula (1): wherein Xand Xare the same as or different from each other, and are each a hydrogen atom, a fluorine atom, or a monovalent organic group; and R is an organic group containing one or more carbon-carbon unsaturated bonds. The method includes reacting an unsaturated cyclic carbonate represented by the following formula (A): wherein Xand Xare defined as described above, and an alcohol represented by the formula (B): R&#x2014;OH, wherein R is defined as described above, or an alkoxide thereof in the presence of a base, or reacting the unsaturated cyclic carbonate and the alkoxide. Also disclosed is a method for producing a cyclic carbonate.

Method for producing cyclic carbonate having unsaturated group, and novel cyclic carbonate

A method for producing lithium fluorosulfonate which includes reacting XSOH, wherein X is a leaving group other than fluorine, with a lithium source and a fluorine source. Also disclosed is a composition containing XSOH.

Lithium fluorosulfonate production method

This invention provides a composition that contains PFOB with a PFOA content lower than that of known PFOB, and that is less likely to have an adverse effect on the environment; and provides a method for producing PFOB. The composition contains CFBrand further contains CFCOOH, wherein CFCOOH is present in a concentration of 25 ppb or less based on the total weight of CFBr. The method for producing CFBr comprises reacting CFI and a brominating agent to obtain CFBr, and alkali-washing the obtained CFBr to reduce the CFCOOH content to 25 ppb or less based on the total weight of CFBr.

Composition containing CFBr and method for producing CFBr

The object of the present invention is to provide a process for producing &#x3b1;-fluoroacrylic acid ester at a high starting material conversion, high selectivity, and high yield. The present invention provides a process for producing the compound represented by the formula (1) wherein R represents alkyl optionally substituted with one or more fluorine atoms, the process comprising step A of reacting a compound represented by the formula (2) wherein X represents a bromine atom or a chlorine atom with an alcohol represented by the formula (3) wherein the symbol is as defined above, and carbon monoxide in the presence of a transition metal catalyst and a base to thereby obtain the compound represented by the formula (1). 

Method for producing &#x3b1;-fluoroacrylic acid ester

The present invention provides a method of producing a fluoropolymer, wherein polymerization using a carboxylate ester bond-containing carboxylic acid derivative as a surfactant in an aqueous medium to give the fluoropolymer is conducted, the above carboxylate ester bond-containing carboxylic acid derivative has a carboxylate ester bond and &#x2014;COOM (M representing H, NH, Li, Na or K), the above carboxylate ester bond may optionally be substituted by fluorine atom.

Method for producing fluorine-containing polymer, aqueous dispersion of fluorine-containing polymer, 2-acyloxycarboxylic acid derivative, and surface active agent

The present invention provides a process for producing a novel compound, i.e., &#x3b1;-chloromethoxycarboxylic acid ester represented by General Formula (1): (CF)C(OCHCl)COOR, wherein R is a hydrocarbon group which may be substituted with at least one atom selected from the group consisting of halogen, oxygen, nitrogen, and sulfur atoms, comprising reacting an &#x3b1;-methoxycarboxylic acid ester represented by General Formula (2): (CF)C(OCH)COOR, wherein R is as defined above, with molecular chlorine; and a process for producing 1,1,1,3,3,3-hexafluoroisopropyl fluoromethyl ether represented by a chemical formula (CF)CH(OCHF), comprising fluorinating and decarboxylating the &#x3b1;-chloromethoxycarboxylic acid ester. According to the present invention, 1,1,1,3,3,3-hexafluoroisopropyl fluoromethyl ether (sevoflurane), which is known as a compound having an anesthetic property, can be produced efficiently and at a low cost.

Carboxylic acid ester, use of the same, and method for producing the same

The present invention provides a process for producing 1,1,1,3,3,3-hexafluoro-2-methoxypropane, wherein a novel compound, 2-methoxy-2-trifluoromethyl-3,3,3-trifluoropropionic acid or a salt thereof is decarboxylated, or wherein an olefin compound represented by chemical formula (4): CF&#x2550;C(CF)(OCH) is reacted with a fluorinating agent; and a process for producing 2-methoxy-2-trifluoromethyl-3,3,3-trifluoropropionic acid or a salt thereof by reacting a hydroxycarboxylic ester with a methylating agent and then hydrolyzing the reaction product, or hydrolyzing the hydroxycarboxylic ester and then reacting the resulting product with a methylating agent. In accordance with the invention, 1,1,1,3,3,3-hexafluoro-2-methoxypropane, which is useful as a raw material for, for example, the anesthetic Sevoflurane, can be produced efficiently and at low cost.

Carboxylic acid compound, use thereof, and process for producing the same

The invention provides a fluoroethercarboxylic acid which is represented by the general formula (I):RfOCHFCFORfCOOM&#x2003;&#x2003;(I)wherein Rfrepresents a partially or fully fluorinated alkyl group, which may optionally be interrupted with one or more oxygen atoms, Rfrepresents a partially or fully fluorinated alkylene group, which may optionally be interrupted with one or more oxygen atoms, and M represents a monovalent alkali metal, NHor H. The fluoroethercarboxylic acid can be suitably used as a surfactant and is low in bioaccumulation. The invention is also a method of fluoropolymer production and an aqueous fluoropolymer dispersion, using the fluoroethercarboxylic acid as a surfactant.

Fluoroethercarboxylic acid and production method thereof, surfactant, method of producing fluoropolymer and aqueous dispersion used thereof

Method for producing fluorine-containing polymer, aqueous dispersion of fluorine-containing polymer, 2-acyloxycarboxylic acid derivative, and surface active agent.

The present invention relates to a method for producing a compound represented by formula (2):[CF(CF)][CF(CF)]C(OH)&#x2003;&#x2003;(2)wherein n and m independently represent 0 to 10, the method comprising reacting with a halogen or a halogen-containing oxidizing agent a salt of a compound represented by formula (1):[CF(CF)][CF(CF)]C(OH)COOH&#x2003;&#x2003;(1)wherein n and m independently represent 0 to 10.

Method for producing hydrate of fluoroalkyl ketone

Method for producing fluorine-containing polymer, aqueous dispersion of fluorine-containing polymer,2-acyloxycarboxylic acid derivative, and surface active agent

The present invention provides a process for the preparation of hexafluoroacetone characterized by bringing hexafluoro-1,2-epoxypropane into contact with at least one catalyst selected from the group consisting of titanium oxide catalysts and fluorinated titanium oxide catalysts to isomerize hexafluoro-1,2-epoxypropane; and a process for the preparation of hexafluoroacetone hydrate characterized by absorbing the hexafluoroacetone prepared by the above process into water to produce crude hexafluoroacetone hydrate, neutralizing the crude hexafluoroacetone hydrate with an alkali, and distilling the resulting mixture. According to the invention, high-purity hexafluoroacetone can be obtained by isomerization of hexafluoro-1,2-epoxypropane with little formation of by-products, and substantially acid-free high-purity hexafluoroacetone hydrate can also be obtained.

Processes for preparation of hexafluoroacetone and its hydrate

A novel 5-fluorouridine derivative of the formula: ##STR1## wherein R.sup.1 is a C.sub.1 -C.sub.10 aliphatic carbonyl group, R.sup.2 is a fluorine atom or a C.sub.1 -C.sub.3 aliphatic carbonyloxy group, and x is a halogen atom such as a fluorine, chlorine, bromine and iodine atom, which is useful as an intermediate in the preparation of a 5-fluoro-2'-deoxyuridine derivative which is useful as an anticancer agent.

5-fluorouridine derivative and preparation of the same

A novel 5-fluorouracil derivative of the formula: ##STR1## wherein R.sup.1 is a fluorine-containing C.sub.1 -C.sub.10 organic group which optionally contains sulfur, oxygen and/or nitrogen. The novel 5-fluorouracil derivative is useful as a carcinostatic substance, which has a high carcinostatic activity but which is less toxicity against digestive tract and causes less autonomic imbalance than other known 5-fluorouracil derivatives.

5-fluorouracil derivatives useful as carcinostatic substances

Growing community of inventors

Settsu, Japan

Yoshihiro Yamamoto