Wakamoto Pharmaceutical Co., Ltd.

Yoshihiro Tsuriya

Toshio Kuroda

Hidekazu Suzuki

Katsuya Ohata

Touru Oguma

Hatsunori Toyofuku

Terumasa Hashimoto

Tooru Abe

Yukiyoshi Yanagihara

Kensaku Miyake

Hitoshi Aoki

Yoshihiro Toyoda

Hiroshi Nagasawa

Shinji Kageyama

Yoshiaki Ogasawara

Hiroko Yageta

Shigekatsu Kohno

Takao Shida

The present invention relates to an anti-inflammatory eye drop comprising a drug selectively inhibiting COX-2, selected from the group consisting of etodolac, N-(2-(cyclohexyloxy)-4-nitrophenyl) methane-sulfonamide and meloxicam, which only slightly damages corneal epithelium and conjunctiva and which is excellent in the anti-inflammatory effect.

Anti-inflammatory eye drop

5-(3-n-Butyloxalylaminophenyl) tetrazole having an excellent SRS-A release-inhibiting effect is used as an effective component for an anti-asthmatic agent, and a pharmaceutical preparation obtained by mixing the tetrazole with a specific dispersant such as polysorbate-80 in coexistence with a non-aqueous solvent shows high dissolubility and bioavailability.

Anti-asthmatic composition and process for preparing the same

New 1,3,4-thiadiazole derivatives of the general formula (I): ##STR1## wherein R.sub.1 represents a group of the formula: ##STR2## and R.sub.2 represents an amino, lower alkylamino, cyclohexylamino, benzoylamino, mercapto or lower alkylthio group, a process for the production of them and the use of the derivatives as antiulcer agents.

1,3,4-thiadiazole derivatives, process for the production thereof and

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Hatano, Japan

Yoshihiro Tsuriya