Daiichi Pharmaceutical Co., Ltd.

Nihon Kohden Corporation

Daiichi Sankyo Company, Limited

Yoshihiro Takayanagi

Akihiro Imura

Tsutomu Yagi

Kouji Sato

Keiji Nakayama

Katsuhiko Okano

Tomoyuki Nagai

Yukinari Kobayashi

Mikihiro Itoh

Seishiro Uchida

Tatsuya Yamaguchi

Masahiro Echigo

Makoto Ono

Katsuyoshi Suzuki

Hitoshi Inaba

Mitsushi Hyogo

Masami Tanishima

Wataru Matsuzawa

Takuya Kawashima

Hiroto Sano

Takayuki Mogi

Katsumasa Imai

A fluid balance management system includes: a detection device configured to output a detection signal corresponding to a load applied to a bed in which a subject is present; a prediction device configured to acquire load variation information indicating a variation over time of the load based on the detection signal, and predict an event that causes variation in fluid balance of the subject from the load variation information; and an output device configured to output prediction information corresponding to a prediction result of the event.

Fluid balance management system, prediction device, learned model generation device, and learned model generation method

The present invention provides an apparatus for controlling body temperature of a patient during hypothermia treatment, comprising: a body trunk cooling unit having a first affixing portion to be applied on a surface of the trunk of a patient's body and for cooling the surface of the trunk of the patient's body; and a body peripheral part heating unit having a second affixing portion to be applied to the peripheral part of the patient's body and for heating the peripheral part of the body by utilizing exhaust heat from the body trunk cooling unit and suppressing activation of cold receptors of the skin of the patient.

Apparatus for controlling body temperature and method thereof

A biological information monitoring apparatus operable to receive biological information measured by a detector adapted to be attached to a patient, and operable to display the biological information on a display, includes: a first display controller which displays an alarm on the display; and a second display controller which displays, on the display, first information which responses to the displayed alarm.

Biological information monitoring apparatus with particular display features

Taxan derivatives are produced efficiently and inexpensively, which are useful as oral-administrable antitumor compounds. A compound of formula (1) (wherein Ris an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, an aryl group or a heterocyclic group; Ris a hydroxyl group optionally having a protective group) is processed with an alkali metal permanganate to produce a compound of formula (2), which may be a starting material for oral-administrable antitumor compounds. 

Method for producing pentacyclic taxans

A crystal of (1S,2S,3R,4S,5R,8R,9S,10R,13S)-4-acetoxy-2-benzoyloxy-9,10-[(1S)-2-(dimethylamino)ethylidenedioxy]-5,20-epoxy-1-hydroxytax-11-en-13-yl (2R,3S)-3-(tert-butoxycarbonylamino)-3-(3-fluoro-2-pyridyl)-2-hydroxypropionate, which has characteristic peaks at diffraction angles (2&#x3b8;) of 6.2&#xb0;, 10.3&#xb0;, 10.7&#xb0;, 11.4&#xb0;, and 12.0&#xb0; in a powder X-ray diffraction pattern, and a method for preparing the aforementioned crystal, which comprises the step of performing crystallization by using an organic solvent selected from the group consisting of a ketone type solvent, a nitrile type solvent, and a mixture thereof, or a mixture of said organic solvent and water.

Crystals of taxane derivative and process for their production

Processes for producing antibacterial agents and intermediates useful in producing antibacterial agents are provided and include producing compound (VI-a) in accordance with the following reaction schema, as well as production intermediates thereof 

Process for producing benzoxazine derivative and production intermediate thereof

Processes for producing antibacterial agents and intermediates useful in producing antibacterial agents are provided and include producing compound (VI-a) in accordance with the following reaction schema, as well as production intermediates thereof.

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Tokyo, Japan

Yoshihiro Takayanagi