Takeda Chemical Industries, Inc.

Hitachi, Ltd.

Takeda Pharmaceutical Company Limited

Yoshihiro Sugihara

Koichi Matsumura

Katsumi Kondo

Teruo Kitamura

Mitsuru Kawada

Masanori Baba

Naoyuki Kanzaki

Osamu Nishimura

Shinichi Imamura

Shohei Hashiguchi

Toshiro Yamashita

Yuka Sudo

Taeko Hattori

Akio Mukoh

Yosei Kuwazuru

Yoshiaki Shimizu

Sachio Shibata

Kouichi Iida

A compound of formula (I) (wherein Ris a hydrogen atom, a hydrocarbon group which may be substituted, a non-aromatic heterocyclic group which may be substituted, Ris a hydrocarbon group which may be substituted, a non-aromatic heterocyclic group which may be substituted, or Rand Rmay combine to each other together with A to form a heterocyclic group which may be substituted; A is N or N&#x2014;R.Y(Ris a hydrocarbon group; Yis a counter anion); Ris a cyclic hydrocarbon group which may be substituted or a heterocyclic group which may be substituted; n is 0 or 1; Ris a hydrogen atom, a hydrocarbon group which may be substituted, a heterocyclic group which may be substituted, an alkoxy group which may be substituted, an aryloxy group which may be substituted, or an amino group which may be substituted, E is a divalent aliphatic hydrocarbon group which may be substituted by group(s) other than oxo; Gis a bond, CO or SO; Gis CO, SO, NHCO, CONH or OCO; J is methine or a nitrogen atom; and each of Q and R is a bond or a divalent Caliphatic hydrocarbon which may be substituted; provided that J is methine when Gis OCO, that one of Q and R is not a bond when the other is a bond and that each of Q and R is not substituted by oxo group(s) when Gis a bond) or a salt thereof has a potent CCR5 antagonistic activity and can be advantageously used for the treatment or prevention of infectious disease of various HIV in human (e.g. AIDS).

Cyclic amine compounds as CCR5 antagonists

A compound of formula (I) (wherein R is a hydrogen atom, a hydrocarbon group which may be substituted, a non-aromatic heterocyclic group which may be substituted, R is a hydrocarbon group which may be substituted, a non-aromatic heterocyclic group which may be substituted, or R and R may combine to each other together with A to form a heterocyclic group which may be substituted; A is N or N &mdash;R .Y (R is a hydrocarbon group; Y is a counter anion); R is a cyclic hydrocarbon group which may be substituted or a heterocyclic group which may be substituted; n is 0 or 1; R is a hydrogen atom, a hydrocarbon group which may be substituted, a heterocyclic group which may be substituted, an alkoxy group which may be substituted, an aryloxy group which may be substituted, or an amino group which may be substituted, E is a divalent aliphatic hydrocarbon group which may be substituted by group(s) other than oxo; G is a bond, CO or SO ; G is CO, SO , NHCO, CONH or OCO; J is methine or a nitrogen atom; and each of Q and R is a bond or a divalent C aliphatic hydrocarbon which may be substituted; provided that J is methine when G is OCO, that one of Q and R is not a bond when the other is a bond and that each of Q and R is not substituted by oxo group(s) when G is a bond) or a salt thereof has a potent CCR5 antagonistic activity and can be advantageously used for the treatment or prevention of infectious disease of various HIV in human (e.g. AIDS).

There are provided with a novel N-substituted-3-halopropiolamide compound, a method of producing the compound, and a composition for controlling noxious organisms containing the compound. The present compound exhibits superior antimicrobial and antifungal effects. Pest control agents containing the compound can advantageously be used for wide applications.

Halopropiolamide compound, production and use thereof

The invention relates to optically active compounds represented by the general formula I ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, Q.sub.1, Q.sub.2, Q.sub.3, and M are defined as in the specification, methods and intermediates for their preparation, liquid crystal compositions comprising at least one optically active compound of formula I and their use in electrooptical display, switching and modulation devices.

Optically active compounds, liquid crystal composition containing said

There are disclosed an optically active compound represented by the general formula: ##STR1## wherein n, R.sub.1, R.sub.2, R.sub.3, R.sub.4, Q.sub.1, Q.sub.2, Q.sub.3, and M are defined as in the detailed explanation, and *-marked carbon atoms are each an asymmetric carbon atom; a liquid crystal composition comprising at least one optically active compound of said general formula and a liquid crystal optical modulator using the composition thereof.

Optically active compound, liquid crystal composition containing said

The present invention discloses dichiral compounds represented by the general formula ##STR1## (R.sub.1, R.sub.2, R.sub.3, R.sub.4, Q.sub.1, Q.sub.2, Q.sub.3, M and n have the same definitions as in the description portion of the specification), intermediates for preparation of said compounds, liquid crystal compositions comprising said compounds, and liquid crystal optical modulators using said compositions.

Optically active compounds, liquid crystal compositions comprising said

This invention relates to novel saccharoascorbic acid derivatives and their production. The derivatives are represented by the general formula set forth below, for example, an amido, a thioester or carboxylic ester of saccharoascorbic acid, and their salts. The compounds of the present invention are useful for food additives as antioxidants, an intermediate for the production of dichiral compounds and medicines having antithrombotic activity. ##STR1## wherein Z represents ##STR2## --SR.sub.6 or --OR.sub.7, R.sub.4 and R.sub.5 independently represent hydrogen or a hydrocarbon group of 1 to 24 carbon atoms, or R.sub.4 and R.sub.5 may together form --CH.sub.2 --.sub.n in which n is an integer of 4 to 7, R.sub.6 represents a hydrocarbon group of 1 to 24 carbon atoms, R.sub.7 represents hydrogen or a hydrocarbon group of 1 to 24 carbon atoms, R.sub.1, R.sub.2 and R.sub.3 independently represent hydrogen, an acyl group of 1 to 18 carbon atoms or a hydrocarbon group of 1 to 24 carbon atoms, and .about. represents the R-configration or the S-configration; provided that when Z is --OR.sub.7, R.sub.1 and R.sub.2 are not the same and R.sub.3 is hydrogen, or a salt thereof.

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Toyonaka, Japan

Yoshihiro Sugihara