Daiichi Sankyo Company, Limited

Toyota Jidosha Kabushiki Kaisha

Trinity Industrial Corporation

Kyb Corporation

Arqule, Inc.

Msd K.k.

Yoshihiro Shibata

Masahiro Ota

Masahiro Ikeda

Hitoshi Ohki

Yasuo Tokushima

Tomoyuki Tsunemi

Zyouzi Itou

Masayuki Kojima

Hideyuki Takata

Shunichi Akiyama

Hidetoshi Omori

Hidemasa Inoue

Michiaki Osawa

Nobuyuki Suzuki

Masanori Ichikawa

Kiyoshi Nakayama

Hiroaki Inagaki

Noriyasu Haginoya

Hidenori Namiki

Yasuhiro Inagaki

Hironao Saito

Shinji Matuura

Masami Ohtsuka

Yasusi Ueda

Hironori Matsunaga

Tooru Okayama

Toshiyuki Nakanishi

Hideaki Watanabe

Takashi Shimada

Jean-Marc Lapierre

Manish Tandon

Yusuke Ota

Craig G Bates

Takeru Yamakawa

Sudharshan Eathiraj

Satoru Ohsuki

Takayuki Momose

Hideki Jona

Yuichi Tominaga

Satoshi Matsui

Takeshi Jimbo

Katsuhiro Kobayashi

Takashi Odagiri

Masanori Saitou

Daisuke Fukatsu

Akitake Yamaguchi

Keijiro Kobayashi

Yoshito Kawamoto

Atsushi Tengeiji

Hideaki Kageji

Yasuyuki Kaneta

Chikahiro Nagata

Rie Ichikawa

Yohei Yoshihama

Akiko Otsuka

Kosuke Takeuchi

The present invention provides a low molecular compound that inhibits phosphatidylserine synthase 1 or a pharmaceutically acceptable salt thereof, a pharmaceutical containing thereof, and a therapeutic agent for cancer having a suppressed function of phosphatidylserine synthase 2. The compound represented by formula (1) or a pharmaceutically acceptable salt thereof, wherein R, ring Q, ring Q, and W are as defined in the specification.

Pyrrolopyrazole derivative

A bracket of a cylinder device includes: a tubular portion having a C-shaped cross section, holding an outer periphery of the outer shell, and having a slit in a front portion; and a pair of mounting portions and protruding outward in the radial direction from both ends of the tubular portion in the circumferential direction. The tubular portion includes a hole formed to permit insertion of the protrusion, from at least one side portion to the back portion of the tubular portion.

Cylinder device and method for manufacturing cylinder device

The application relates to a compound of Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which modulates the activity of BTK, a pharmaceutical composition comprising a compound of Formula (I), and a method of treating or preventing a disease in which BTK plays a role.

Amino-pyrrolopyrimidinone compounds and methods of use thereof

The present invention relates to a compound having RET kinase inhibiting action or a pharmaceutically acceptable salt thereof, useful in the treatment of diseases such as cancer. In particular a compound represented by the following general formula (I) as defined herein: (I) or a pharmaceutically acceptable salt thereof. 

Pyridine compound

Novel compounds or salts thereof, or crystals thereof, which inhibit Axl and are useful for treating diseases caused by Axl hyperfunction, diseases associated with Axl hyperfunction and/or diseases accompanied by Axl hyperfunction are provided. Pyridone derivatives represented by the formula (1) having various substituents or salts thereof, or crystals thereof (where R, R, R, R, R, A, W, X and n in the formula (1) are as defined in the specification, respectively) are provided.

Pyridone derivatives

A compound represented by formula (I) having mTOR inhibitory activity or a pharmacologically acceptable salt thereof.

Imidazopyridin-2-one derivatives

The invention relates to a compound of a general formula (I): wherein A represents a linking group; Arrepresents a group formed from an aromatic ring; Rand Reach independently represent a hydrogen atom, a halogen atom, a cyano group, a C2-C6 alkenyl group, a C1-C6 alkoxy group, a halo-C1-C6 alkoxy group, a cyclo-C3-C6 alkyloxy group, a C2-C7 alkanoyl group, a halo-C2-C7 alkanoyl group, a C2-C7 alkoxycarbonyl group, a halo-C2-C7 alkoxycarbonyl group, a cyclo-C3-C6 alkyloxycarbonyl group, an aralkyloxycarbonyl group, a carbamoyl-C1-C6 alkoxy group, a carboxy-C2-C6 alkenyl group, or a group of -Q-N(R)-Q-R; a C1-C6 alkyl group optionally having substituent(s); an aryl or heterocyclic group optionally having substituent(s); or a C1-C6 alkyl group or a C2-C6 alkenyl group having the aryl or heterocyclic group; T and U each independently represent a nitrogen atom or a methine group; and V represents an oxygen atom, a sulfur atom or an imino group. The compound of the invention is useful as therapeutical agents for various ACC-related diseases. 

Spirochromanone carboxylic acids

A pyrazolopyrimidine compound represented by formula (1) that inhibits the function of HSP90 as a chaperone protein and that has antitumor activity, a medicament comprising a compound represented by formula (1), a pharmaceutical composition comprising a compound represented by formula (1), and a method for treating cancer using a compound represented by formula (1). 

Tricyclic pyrazolopyrimidine derivatives

A compound represented by formula (I) having mTOR inhibitory activity or a pharmacologically acceptable salt thereof. 

Problem to be Solved To provide a novel compound inhibiting the effect of HSP90, in particular a novel compound inhibiting the function of HSP90 as a chaperone protein and having antitumor activity. Solution The present invention provides a pyrazolopyrimidine compound represented by the formula (1) having various substituents which inhibits the ATPase activity of HSP90 and which has antitumor activity, an HSP90 inhibitor comprising the compound represented by the formula (1), a medicament comprising the compound represented by the formula (1), an anticancer agent comprising the compound represented by the formula (1), a pharmaceutical composition comprising the compound represented by the formula (1) and a method for treating cancer using the compound represented by the formula (1). 

Pyrazolopyrimidine derivative

A method of operating an air-supplied type coating booth in which conditioned air supplied from an air supply blower is enforced downwardly to the inside of a tunnel-shaped coating booth and the air in the coating booth is drawn together with paint mists and the likes down to the beneath of a booth floor by way of an air exhaust blower comprises the steps of detecting the flow velocity of air streams flowing into or out of inlet and the exit of the coating booth, applying primary and secondary averaging processings for signals for averaging variations caused by external disturbances fluctuating at relatively shorter and longer periods of time, judging the thus averaged direction and the flow velocity of the air streams at the inlet and the exit, variably controlling the flow rate of exhaust from the exhaust blower in accordance with the direction and the flow velocity. The exhaust blower means are divided into a plurality of blowers and the minute variations in the direction and the flow velocity are controlled excessively by the blowers situated at the inlet and the exit of the coating booth, while remaining exhaust blowers are operated at predetermined flow rate.

Method of operating an air-supplied type coating booth

A method of operating an air-supplied type coating booth in which conditioned air is enforced from an air supply blower downwardly to the inside of a coating booth and then discharged to the beneath of the booth floor by an exhaust blower, in which the booth operation is stopped after memorizing the balanced flow rates for the supply blower and the exhaust blowers kept just before the completion of the booth operation, and the supply blower and the exhaust blower are automatically set to the above-mentioned balanced flow rates respectively upon re-starting the booth operation again. Balanced and stable booth operation where no air streams flow into or out of the inlet and the exit can be attained rapidly at the start of the booth operation.

Method of operating an air supplied type coating booth

A method of operating an air-supplied type coating booth adapted to enforce conditioned air by an air supply blower through a filter downwardly to the inside of a tunnel-shaped coating booth at a predetermined flow velocity and then drawn to discharge together with coating mists, etc. to the beneath of the floor comprises the step of detecting the flow velocity of conditioned air flowing through the filter to the inside of continuously, applying primary and secondary averaging processings for the detected signals containing variations fluctuating at relatively shorter and longer periods respectively, comparing the value obtained from the signals applied with the secondary averaging processing with a predetermined flow velocity value and variably controlling the flow rate of the air supplied from the air supply blower depending on the deviation and thereby maintaining the flow velocity of the conditioned air flowing to the inside of the coating booth always constant. Reduction of the flow velocity supplied to the inside of the air-supplied type coating booth due to the filter clogging can be compensated exactly with no effects of external disturbances.

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Tokyo, Japan

Yoshihiro Shibata