Takeda Pharmaceutical Company Limited

Yoshihiro Omachi

Masami Kusaka

Yutaka Tanoue

Hiroto Bando

Takashi Kurasawa

Yumiko Ishii

Masao Nagao

Kenichiro Kiyoshima

Yasuhiro Hiraishi

Yasuko Watanabe

Tomoyuki Manoshiro

Shigehiro Asano

The present invention provides a microneedle patch which can solve the problem that microneedle production is difficult and requires high accuracy, the problem that time and mental burdens on a health professional and a patient are large, and the problem caused by compounding a plurality of drugs. The microneedle patch comprises a large number of drug-carrying microprojectionserected on one support sheet, each microprojectionhaving a drug layersoluble in vivo at its top part and having an intermediate layerunder the drug layer, the intermediate layercontaining a polymeric substance for adhesion of the drug layerto the support sheet, the drug layerat the top part of the microprojectioncontaining a single drug, the microprojectionsholding difference types of drugs being arranged together on the support sheet

Microneedle patch

The present invention provides a preparation containing pioglitazone or a salt thereof as an active ingredient, which shows high bioavailability of pioglitazone and less interindividual variation in blood drug concentration, as well as a preparation with suppressed color change during preservation. The preparation contains a core containing a pharmaceutically acceptable organic acid with water solubility at 20&#xb0; C. of not less than 10 mg/mL and pK(a negative common logarithm of the first acid dissociation constant K) at 25&#xb0; C. of not more than 5, and a coating layer containing pioglitazone or a salt thereof. The coating layer may further contain mannitol or trehalose.

Coated preparation

The present invention provides an orally-disintegrating solid preparation such as a tablet produced by tabletting fine granules showing controlled release of a pharmaceutically active ingredient and an additive, and the like, and the orally-disintegrating solid preparation containing fine granules coated with a coating layer containing a polymer affording a casting film having an elongation at break of about 100-about 700%. With the preparation, breakage of fine granules during tabletting can be suppressed in the production of an orally-disintegrating solid preparation containing fine granules showing controlled release of a pharmaceutically active ingredient.

Orally-disintegrating solid preparation

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Osaka, Japan

Yoshihiro Omachi