Wakunaga Pharmaceutical Co., Ltd.

Wakunaga Seiyaku Kabushiki Kaisha

Wakunaga Pharmaceuticals Co., Ltd.

Yoshihiro Ohshita

Akira Yazaki

Norihiro Hayashi

Hirotaka Amano

Yuzo Hirao

Yasuhiro Kuramoto

Yoshiko Niino

Jiro Yoshida

Kenji Itoh

Nobuya Sakae

Toyoharu Hozumi

Kazusa Yoshikai

Hitomi Takenaka

Tamae Yamane

Takayuki Amago

The present invention provides an agent which exhibits excellent antibacterial activity, low toxicity, improved bioavailability, and low binding rate to serum proteins. The present invention is directed to a pyridonecarboxylic acid derivative represented by formula (1): or a salt thereof, wherein Rrepresents a methyl group, a fluorine atom, or a chlorine atom; Rrepresents a hydrogen atom or a lower alkyl group; Rrepresents an isopropyl group or a tert-butyl group; Rrepresents a methyl group or a halogen atom; and Rrepresents a fluorine atom or a chlorine atom. The present invention is also directed to an antibacterial agent and a medicament containing the derivative or the salt thereof as an active ingredient.

Pyridonecarboxylic acid derivatives or salts thereof

This invention relates to 1-(6-amino-3,5-difluoropyridin-2-yl)-8-bromo-7-(3-ethylaminoazetidin-1-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid or a salt thereof, and also to a medicine containing the same. This compound has characteristic features that, when administered orally, it has extremely high blood half-life and bioavailability while retaining properties that it has extremely high antimicrobial effects and has low toxicity. It can be used widely as preventives, therapeutics and the like for various infectious diseases of human and animals.

Quinolinecarboxylic acid derivative or salts thereof

Pyridonecarboxylic acid derivatives or salts thereof and antibacterial agents containing the same as the active ingredient

A pyridonecarboxylic acid derivative represented by the following general formula (1): ##STR1## [wherein R.sup.1 represents hydrogen atom or a carboxyl protective group; R.sup.2 represents hydroxyl group, a lower alkoxy group, or a substituted or unsubstituted amino group; R.sup.3 represents hydrogen atom or a halogen atom; R.sup.4 represents hydrogen atom or a halogen atom; R.sup.5 represents a halogen atom or an optionally substituted saturated cyclic amino group; R.sup.6 represents hydrogen atom, a halogen atom, nitro group, or an optionally protected amino group; X, Y and Z may be the same or different and respectively represent nitrogen atom, --CH.dbd. or --CR.sup.7 .dbd. (wherein R.sup.7 represents a lower alkyl group, a halogen atom, or cyano group) (with the proviso that at least one of X, Y and Z represent the nitrogen atom), and W represents nitrogen atom or --CR.sup.8 .dbd. (wherein R.sup.8 represents hydrogen atom, a halogen atom, or a lower alkyl group)] or its salt, as well as an antibacterial agent containing such compound are provided.

Pyridonecarboxylic acid derivatives or their salts, and antibacterial

Pyridonecarboxylic acid derivatives or salts thereof and drugs

Pyridonecarboxylic acid derivatives or their salts and antibacterial

Pyridonecarboxylic acid derivatives or salts thereof and antibacterial

A slide glass comprising a slide glass structure having a glass surface with silicic acid groups and a lipophilic functional group introduced into at least a part of said silicic acid groups. By the lipophilic group thus introduced, peel-off of the cell specimen does not readily occur.

Slide glass

Growing community of inventors

Akitakata, Japan

Yoshihiro Ohshita