Otsuka Pharmaceutical Company, Limited

Yoshihiro Masui

Satoru Nakai

Takashi Kamogashira

Yoshikatsu Hirai

Koutoku Aihara

Kazuyoshi Kawai

Mayumi Kaneta

Seiji Akamatsu

Tsutomu Nishida

Yoshikatu Hirai

The present invention provides a medicament for treating thrombocytopenia comprising as an active component at least one polypeptide selected from IL-1 and derivative thereof and a Il-1.alpha. derivative having an amino acid sequence of the formula (.alpha.) which is so modified as to fulfill at least one of the requirements of: deletion of the 16-position Arg; replacement of the 16-position Arg by another amino acid residue; deletion of the sequence of the 1-position Ser to the 14-position Phe and deletion of the amino acid sequence of the 1-position Ser to the 15-position Met.

IL-1.alpha. derivatives

A drug for preventing and curing liver diseases comprising at least one member selected from interleukin-1 and its derivatives as an effective component. The drug meaningfully suppresses GOT and GPT activities in blood which are markers of liver diseases, and also suppresses symptoms such as choloplania.

Use of interleukin-1 (IL-1) to inhibit development of hepatitis

The present invention provides a medicament for treating thrombocytopenia comprising as an active component at least one polypeptide selected from IL-1 and derivative thereof and a IL-1.alpha. derivative having an amino acid sequence of the formula (.alpha.) which is so modified as to fulfill at least one of the requirements of: deletion of the 16-position Arg; replacement of the 16-position Arg by another amino acid residue; deletion of the sequence of the 1-position Ser to the 14-position Phe and deletion of the amino acid sequence of the 1-position Ser to the 15-position Met.

IL-1.alpha. derivatives and medicament for treating thrombocytopenia

Growing community of inventors

Tokushima, Japan

Yoshihiro Masui