Olympus Corporation

Olympus Optical Company, Ltd.

Olympus America Inc.

Olympus Corpration

Yoshihiro Kawano

Yoshihisa Tanikawa

Tadashi Hirata

Atsuhiro Tsuchiya

Kimihiko Nishioka

Kazuo Kajitani

Keiji Shimizu

Tatsuo Nakata

Toyoharu Hanzawa

Hiroshi Ishiwata

Masaaki Yamagishi

Isao Ishibe

Shinichi Nakamura

Akira Hasegawa

Yasushi Fujimoto

Hisashi Goto

Hiroshi Sasaki

Hideaki Yoshida

Atsushi Miyawaki

Susumu Honda

Kenichi Koyama

Tsutomu Uzawa

Takashi Fukaya

Hiroshi Fujiwara

Kazuhiro Hayashi

Takashi Kasahara

Keiji Kimura

Hiroya Fukuyama

Susumu Kikuchi

Tomonori Ishikawa

Yasuaki Natori

Minoru Sukekawa

Masahiko Kinukawa

Iwao Kanamori

Masahiro Oba

Tsuyoshi Mochizuki

Shuzo Mishima

Shigeo Tokunaga

Chika Nakajima

Masami Hamada

Takashi Fukano

Kei Tsuyuki

Hiroyuki Kurita

Yasushi Kaneko

Takao Yamauchi

Mitsumori Hayashida

Kiyoshi Koike

Lorne D Davies

Yoshiaki Sano

Itaru Endou

Asuka Yamamoto

Provided is a specimen staining apparatus that includes a gap-forming member arranged to form a gap having a thickness that induces capillary action, the gap being formed above a mounting surface of a slide glass having a specimen mounted thereon; and a chemical solution supply unit that supplies a chemical solution for staining the specimen to the gap between the gap-forming member and the mounting surface so that the chemical solution spreads within the gap due to capillary action and is evenly supplied to the specimen placed on the mounting surface.

Specimen staining apparatus and specimen staining method

It is possible to readily observe pathology specimens without spending much time and suspected pathology specimens in detail. A specimen observation device comprises an image capturing unit acquiring a partial image representing at least a part of one of multiple pathology specimens mounted on an accommodating section and a whole image of the multiple pathology specimens mounted on the accommodating section; an input unit inputting identification information of the accommodating section; a display unitdisplaying an enlarged version of the partial image acquired by the image capturing unit); an image designating unit designating the partial image displayed on the display unit; and a storage unit storing the identification information input via the input unit and a position of the partial image designated via the image designating unit in relation to the whole image such that the position and the identification information are associated with the whole image.

Specimen observation device

A microscope apparatus according to the present invention includes a bright-field illumination optical system and a fluorescence illumination optical system that respectively radiate illumination light and excitation light onto a sample, an observation optical system that observes observation light from the sample, and a controller that controls the fluorescence illumination optical system so that the excitation light is radiated onto the sample when the irradiation of the illumination light on the sample is prevented by an irradiation preventing portion of the bright-field illumination optical system and so that the irradiation of the excitation light on the sample is prevented when the irradiation of the illumination light on the sample is not prevented by the irradiation preventing portion.

Microscope apparatus

A wide field microscopic image acquisition apparatus and method are disclosed. The apparatus is configured to acquire images of a specimen on a microscope slide and includes first and second illuminators each having unique illumination characteristics. The apparatus includes a microscope imaging system with an imaging device, an objective lens and a stage configured to digitally acquire a plurality of images of the specimen using the first and second illuminators. A controller is configured to automatically control the microscope imaging system and acquire the plurality of images of the specimen using the first and second illuminators. The first and second illuminators can be bright field, dark field or fluorescent illuminators.

Wide field microscopic imaging system and method

A microscope for virtual-slide creating system has a stage for holding the specimen, a transmitted-light illumination optical system for illuminating the specimen with transmitted light, an objective, a tube lens and an image capture unit. The objective is configured as a dry system of infinity-corrected type with an object-side numerical aperture of 0.8 or greater and a focal length for d-line rays in a range from 8 to 20 mm. The tube lens has a focal length in a range from 160 to 280 mm. The image capture surface of the image capture unit has a long side of 12 mm or longer and a pixel size (&#x3bc;m) satisfying the following condition:(&#x3bc;m)&#x2266;(0.61&#xd7;0.59 (&#x3bc;/m))/where a is the pixel size, and NA' is an image-side numerical aperture.

Microscope for virtual-slide creating system

The present invention prevents the leakage of anesthetic gas, and enables in vivo observation of a specimen such as small laboratory animals over a long period of time. An in-vivo examination apparatus () comprises: a stage () for mounting a specimen (A) such as a laboratory animal; an anesthetizing chamber () which is disposed on the stage () for housing the specimen (A); and an anesthetic gas supply device () for supplying anesthetic gas (G) into the anesthetizing chamber (); wherein a transparent window () is provided on at least a part of the anesthetizing chamber ().

In-vivo examination apparatus

The present invention is a virtual-slide specimen image acquisition apparatus that captures images by dividing a specimen into a plurality of sections, having a conveying device in which a plurality of specimens can be arranged and that conveys the plurality of the arranged specimens in a first direction by a distance corresponding to the length of a side along the first direction in one of the divided sections and at first time intervals and an image capturing device that has an image capturing portion for capturing images of the specimens magnified at a predetermined magnification and that scans the specimens conveyed to a predetermined position in a second direction, by a predetermined length at second time intervals, such that the image capturing portion captures images of all of the sections that are positioned identically in the first direction and that are positioned differently in the second direction perpendicular to the first direction.

Virtual-slide specimen image acquisition apparatus

An object is to easily and reliably reach an examination site. The present invention provides an examination method of carrying out in-vivo examination using an in-vivo examination apparatus capable of fluorescence examination and reflected-light examination and includes the steps of setting a reference position so as to set an examination site by carrying out reflected-light examination, switching from reflected-light examination to fluorescence examination, and moving from the reference position to the examination site.

In-vivo examination method and in-vivo examination apparatus

The invention provides an examination apparatus including an objective optical system for positioning a focal point inside a specimen mounted on a stage; an image-acquisition apparatus for detecting light emitted in different optical-axis directions from the vicinity of the focal point inside the specimen and collected by the objective optical system to acquire a plurality of pieces of image information; and a three-dimensional image forming unit for forming a three-dimensional image of a light-emitting site in the vicinity of the focal point based on the plurality of pieces of image information acquired by the image-acquiring apparatus.

Examination apparatus

When carrying out in vivo examination of a living organism, the behavior in the interior thereof is continuously observed with clear images. Provided is an in-vivo examination apparatuscomprising an optical unitincluding a light sourceand an image acquisition device; and an observation head, which is disposed with a gap with respect to the optical unitand which is fixed to a living organism A, wherein the optical unitincludes a first collimator optical systemfor converting light from the light sourceinto collimated light Land introducing it into the observation headand an image-forming optical systemfor focusing return light from the observation headto form an image at the image-acquisition device, and wherein the observation optical headincludes a second collimator optical systemfor focusing the collimated light Lincident from the optical unitto irradiate an examination target site B in the living organism A, as well as for converting return light from the living organism into collimated light Land introducing it into the optical unit

A microscope examination apparatus is provided that includes a light source for emitting excitation light or illumination light to a specimen placed on a stage; an objective lens opposing the stage and capable of focusing fluorescence or reflected light from the specimen; an image-forming lens for forming an image of the specimen obtained by the objective lens; and an image-capturing unit for capturing the image of the specimen forming by the image-forming lens, wherein a plurality of the objective lenses having different magnifying powers is provided, and an objective-lens switching mechanism for switching among the objective lenses is provided, and wherein a plurality of the image-forming lenses having different magnifying powers is provided, and an image-forming-lens switching mechanism for switching among the image-forming lenses is provided.

Examination apparatus, fluoroscopy apparatus, examination method, and experimental method

A focusing method for an examination apparatus that can quickly and easily perform focusing for fluoroscopy is provided. The focusing method, for an examination apparatus that can observe fluorescence emitted from a specimen, includes a first step of irradiating the specimen with light via an objective lens to generate reflected light and fluorescence; a second step of performing focusing with respect to the surface of the specimen using the reflected light from the specimen; and a third step of performing focusing for the fluorescence based on the focal position of the specimen surface in the second step.

Examination apparatus and focusing method of examination apparatus

A scanning optical microscope including: a light source; a lens for altering the cross-sectional shape aspect ratio of a beam of light emitted from the light source; at least one lens for converging beams of light of different cross-sectional shape aspect ratio to create a linear light; a first light modulation member able to impart shade to the converged linear light; a lens that can form the light to which the shade has been imparted as a parallel light; a scanning member that can alter the angle of illumination; a lens for focusing the light to which the shade has been imparted; an objective lens for projecting the light to which the shading has been imparted to a sample body; and a lens for imaging the reflected light from the sample body or the light generated by the sample body on to a sensor.

Confocal microscope

A microscope system includes a light source and an objective unit. The objective unit includes an objective optical system, including a small-diameter distal optical system arranged at an end brought near to or into contact with a specimen, for focusing light from the light source onto the specimen; a threaded mount at a coupling position; and an outer cylinder enclosing the small-diameter distal optical system. The microscope system further includes an imaging optical system for forming an image of light from the specimen through the objective optical system and a microscope main body for housing the imaging optical system. The objective unit is detachable from and attachable to the microscope main body with the threaded mount. Conditional expression Df/Da&#x2266;0.3 is satisfied, where Df represents the outer diameter of the outer cylinder and Da represents the outer diameter of the threaded mount.

Microscope system and objective unit

Growing community of inventors

Hachioji, Japan

Yoshihiro Kawano