Pfizer Corporation

Other

Yoshihiro Katoh

Kim Jonelle Stutzman-Engwall

Hamish A McArthur

The present invention relates to polynucleotide molecules comprising sequences encoding avec gene products, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of. AveC genes, homologs and partial homologs thereof are described for, and, respectively. The present invention further relates to vectors, host cells, and mutant strains ofin which the avec gene has been inactivated, or mutated so as to change the ratio or amount of class 2:1 avermectins produced.

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The present invention relates to polynucleotide molecules comprising sequences encoding avec gene products, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of . AveC genes, homologs and partial homologs thereof are described for , S. hygroscopicus, and , respectively. The present invention further relates to vectors, host cells, and mutant strains of in which the avec gene has been inactivated, or mutated so as to change the ratio or amount of class 2:1 avermectins produced.

AveC gene product from Streptomyces hygroscopicus

The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of . The present invention further relates to vectors, host cells, and mutant strains of in which the aveC gene has been inactivated, or mutated so as to change the ratio or amount of class 2:1 avermectins produced.

Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins

The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding the aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of The present invention further relates to vectors, host cells, and mutant strains of in which the aveC gene has been inactivated, or mutated so as to change the ratio or amount of class 2:1 avermectins produced.

Methods related to Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins

The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of,. The present invention further relates to vectors, host cells, and mutant strains of,in which the aveC gene has been inactivated, or mutated so as to change the ratio or amount of class 2:1 avermectins produced.

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Aichi, Japan

Yoshihiro Katoh