Dainippon Sumitomo Pharma Co., Ltd.

Sumitomo Dainippon Pharma Co., Ltd.

Yoshihiro Horiuchi

Nobuhisa Fukuda

Katsunori Tsuboi

Hiroaki Fujiwara

Fumio Samizo

Kiyoto Sawamura

Atsushi Makita

Izumi Sasaki

Hitoshi Suda

Mitsutaka Iwata

Disclosed is a compound represented by formula (1) or a pharmacologically acceptable salt thereof (In the formula, A represents a group that is represented by formula (A-1); Rand Rmay be the same or different and each independently represents a Calkyl group which may be substituted by one to three halogen atoms; m and n each independently represents an integer of 0-5; Xrepresents a hydroxyl group or an aminocarbonyl group; Zrepresents a single bond or the like; and Rrepresents an optionally substituted Calkyl group, an optionally substituted Caryl group or the like). 

8-azabicyclo[3.2.1]octane-8-carboxamide derivative

Provided is a compound represented by formula (1) or a pharmacologically acceptable salt thereof. (In the formula, A is Carylene, etc.; R, Rand Reach independently is a hydrogen atom, a halogen atom, a Calkyl group, a Calkoxy group, etc.; Ris an optionally substituted Caryl group, an optionally substituted 5- to 12-membered monocyclic or polycyclic heteroaryl group, an optionally substituted Caralkyl group, etc.; m is 0, etc.; n is an integer of 0 to 2.) 

Cyclic amide derivative

A medicine which contains as an active ingredient a benzothiazin-3-one-compound represented by the formula (1): (wherein n is 3 or 4; R represents ethyl or hydrogen; and Rrepresents hologeno, alkoxy, haloalkyl, or haloalkoxy) or a pharmaceutically acceptable salt thereof. It is useful as a therapeutic or preventive agent for arthrosis deformans, chondrodegenerative discases such as chronic articular rheumatism, cancers, gingivitis, etc. Also provided are an intermediate for the compound and a process for producing the compound.

Benzothiazin-3-one compound and intermediate therefor

A hydroxamic acid derivative represented by the following general formula (1) having selective MMP inhibitory activity, wherein Rand Reach represents hydrogen atom, lower alkyl group, lower haloalkyl etc., X represents methylene group or NR(Rrepresents hydrogen atom, lower alkyl group, etc.), and Rrepresents C1&#x2dc;4 lower alkyl group.

Hydroxamic acid derivative and MMP inhibitor containing the same as active ingredient

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Osaka, Japan

Yoshihiro Horiuchi