Eisai Company, Limited

Yoshihiko Hisatake

Takashi Sato

Hiroshi Kuroda

Hiroshi Yoshino

Yutaka Tsuchiya

Masahiko Tsujii

Masayuki Konishi

Atsushi Koiwa

Mikio Uchiyama

Shizumasa Kijima

Kimio Hamamura

Tomio Tsurugi

Yoshio Urawa

Yukio Narabe

Takuo Tanaka

The present invention provides a novel industrially excellent and ecological process for producing methylcobalamin which is useful as a medicament etc. More specifically, it provides a process for producing methylcobalamin by reducing cyanocobalamin or hydroxocobalamin in the presence of a reducing agent, and then methylating the reductant by adding a water-soluble methylating agent.

Process for producing methylcobalamin

The present invention provides an industrially excellent and novel process for producing methylcobalamin useful as medicines. Namely, it provides a process for producing methylcobalamin, which comprises the step of methylating cyanocobalamin or hydroxocobalamin in the presence of a reducing agent and a water-soluble methylating agent.

Process for production of methylcobalamin

A terpene derivative represented by the general formula (I): ##STR1## wherein R.sup.1 represents a lower alkyl group; R.sup.2 represents an alkyl group, a cycloalkyl group, a cycloalkylalkyl group, an aryl group, an arylalkyl group or a heteroaryl group; n is 0 or 1 or 2; and the symbol '  ' represents a single or double bond with the proviso that both of the linkages adjacent to each other are not simultaneously single bonds or double bonds which are useful for the preparation of drug, food, perfume and so on, and a process for preparing thereof.

Terpene derivatives and process for preparing the same

Purified secretin is obtained by subjecting crude secretin to reversed-phase high-performance liquid chromatography using, as an eluant, a solvent mixture of an acid or salt thereof and an organic solvent.

Process for purifying secretin

A heptacosapeptide having the following structural formula:

Heptacosapeptide

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Ibaraki, Japan

Yoshihiko Hisatake