Mitsubishi Chemical Industries Limited

Merck + Co., Inc.

Mitsubishi Kasei Corporation

Yoshiharu Morita

Tadashi Shirasaka

Naoshi Imaki

Junichi Ohya

Hisao Takayanagi

Tetsuro Shimpuku

Yuki Takuma

Kazuo Wagatsuma

Koichiro Hirayama

Kenzo Omata

Junko Takashima

Yasuo Hoshide

Arthur A Patchett

Masao Taniguchi

Haruyuki Chaki

Mari Oishi

Ryoichi Ando

Tsuyoshi Ito

Takaharu Itagaki

Kohei Umezu

Louis Chaiet

Shigenori Wada

Shuzo Hayakawa

Yoshihiro Tanaka

Osamu Kawashima

Saburo Hattori

Yoshio Ihashi

Tadao Sato

Hiroshi Terayama

Eiichiro Tanaka

Kazumasa Kinugasa

According to the present invention, there is provided an anti-solid tumor agent comprising a cembrane-type compound represented by the general formula (I) or (II): ##STR1## wherein R is a hydrogen atom or an acyl group, as an effective ingredient.

Anti-solid tumor agents

New phosphonic acid derivatives are described which display antibacterial activity.

1-aminoethyl phosphonic acid derivatives

Phosphinic acid derivatives

New peptide derivatives .beta.-chloro-L-(Z)-dehydroglutamic acid are described which display antibacterial activity.

Peptide derivatives of .beta.-chloro-L(Z)-dehydro-glutamic acid

Disclosed are some new aminoethylphosphinic acid derivatives useful as antibacterial agents.

Aminoethylphosphinic acid derivatives

A process for preparing cotarnine is provided which comprises oxidizing the amino group of a tetrahydroisoquinoline compound represented by the following formula (I): ##STR1## to convert said compound into a dihydroisoquinolinium salt represented by the following formula (II): ##STR2## wherein A.sup.- represents an anion, and then hydrolyzing said dihydroisoquinolinium salt.

Process for preparing cotarnine

Anti-tumor promoter agents

There is provided a novel benzylamine derivative of the formula I: ##STR1## wherein R.sup.1 represents a hydrogen atom or a methyl group, X represents a hydrogen atom, a methyl group or a tosyl group, and Y represents a hydrogen atom, a methyl group or ##STR2## in which R.sup.2 and R.sup.3 being identical or different from each other represent independently a lower alkyl group.

Benzylamine derivative

A tetrahydroisoquinoline derivative represented by formula: ##STR1## wherein R.sup.1 represents hydrogen or methyl and X.sup.1, X.sup.2, Y.sup.1 and Y.sup.2 are defined as follows:

Certain 6,7-methylene dioxydihydro or tetrahydro-isoquinoline derivatives

There is provided a novel anisole derivative represented by the following formula (I): ##STR1## wherein A to D are defined as follows: (1) A, B and C are each a hydrogen atom, and D represents --OH, a halogen atom, --CO.sub.2 R.sup.1 of which R.sup.1 represents a lower alkyl group, --SO.sub.2 R.sup.2 of which R.sup.2 represents a lower alkyl group, or ##STR2## or (2) A and C are each a hydrogen atom, B is --OH, and D represents --CO.sub.2 R.sup.3 of which R.sup.3 represents a lower alkyl group; or

Anisole derivatives

Disclosed herein is a process for preparing phthalide derivatives represented by the general formula (IV): ##STR1## wherein R.sup.1 to R.sup.7 are herein defined, comprising (i) reacting a nitrophthalide of the general formula (I) defined herein with an isoquinoline of the general formula (II) defined herein, and (ii) reducing the resultant phthalideisoquinoline of the general formula (III) defined herein. The process is characterized in (A) that the reaction defined in (i) is carried out in methanol, and/or (B) that the nitrophthalide of the general formula (I) is a nitrophthalide obtained by a reaction of a phthalide of the general formula (V) defined herein with copper nitrate or zinc nitrate.

Process for preparation of phthalide derivatives

Process for producing an estrone acetal

Cysteine derivatives

This invention relates to a method for synthesizing a penicillin by reacting a silylate of 6-aminopenicillanic acid and a carboxylic acid halide in the presence of an insoluble weakly basic resin having a three-dimensional structure.

Method for synthesis of penicillin

Growing community of inventors

Yokohama, Japan

Yoshiharu Morita