Takeda Chemical Industries, Inc.

Daikyo Gomu Seiko, Ltd.

Yoshiharu Matukura

Hiroshi Fujisawa

Akihiro Nagai

Etsunosuke Noda

Yasushi Mikura

Denpei Sudo

Tokio Kataoka

The present invention relates to a stabilized aqueous suspension of oxendolone, which contains 0.05 to 1.0 w/v percent of a nonionic surfactant and 0.01 to 0.25 w/v percent of a p-hydroxybenzoic acid ester. The suspension satisfy the requirements of a pharmaceutical preparation and shows a prolonged activities of oxendolone without accompanying pain when it is injected.

Aqueous suspension of oxendolone

A pierceable closure member for use on a vacuum-filled vial, including a rubber plug having an annular leg and an annular protrusion, and a lamina having an annular recess and secured to the rubber plug with the annular recess receiving therein the annular leg. For the purpose of retaining the vacuum inside the vial, the annular protrusion on the rubber plug has a specific dimensional relationship to the other parameter of the closure member.

Pierceable closure member for vial

A rubber closure device for closing the mouth of a vial or like vessel comprises an inner closure member having a leg portion adapted to tightly protrude into the mouth, and an overlay closure member overlaying the inner closure member. The inner closure member is made of fluorinated rubber and has a thickness sufficient to exhibit a resistance to chemicals.

Rubber closure device for vials

An injectable solution containing a trihydric to hexahydric sugar alcohol together with L-pyroglutamyl-L-histidyl-L-prolinamide or a physiologically acceptable salt thereof shows significantly reduced pain when administered to a host, especially subcutaneously or intramuscularly.

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Ikoma, Japan

Yoshiharu Matukura