Takeda Chemical Industries, Inc.

Yoshiharu Maeda

Mitsuhisa Yamano

Tetsuya Tsukamoto

Yukio Ishibashi

Motoki Ikeuchi

Shigeo Yabuno

Yukio Mizuno

Atsushi Inagaki

Akira Nakatani

Masahiro Mizuno

Production of optically active benzothiepin salts

Processes for production of quinoline or quinazoline derivatives and

Crystalline acetoxymethyl and pivaloyloxymethyl esters of (+)-(5R, 6S)-6-[(R)-1-hydroxyethyl]-3-(3-pyridyl)-7-oxo-4-thia-1-azabicyclo-[3.2.0] hept-2-ene-carboxylic acid can be obtained by adding a poor solvent to a solution of acetoxymethyl or pivaloyloxymethyl ester of (+)-(5R, 6S)-6-[(R)-1-hydroxyethyl]-3-(3-pyridyl)-7-oxo-4-thia-1-azabicyclo-[3.2.0] hept-2-ene-carboxylic acid in a good solvent. The crystalline penem compounds obtained show improved stability and are useful antibacterial agents.

Crystalline esters of (+)-(5R,

Crystals of 7.beta.-[(Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyiminoacetamido]-3- (1-imidazo[1,2-b]pyridazinium)methyl-3-cephem-4-carboxylate hydrochloride or a solvate thereof, which are stable and improved in solubility in water, are useable for an excellent antibacterial agent.

Crystals of cephem hydrochloride

Growing community of inventors

Osaka, Japan

Yoshiharu Maeda