Osaka University

Yoshifumi Shirakami

Hayato Ikeda

Yoshikatsu Kanai

Eku Shimosegawa

Kazuko Kaneda

Tadashi Watabe

Jun Hatazawa

Atsushi Shinohara

Koichi Fukase

Yasukazu Kanai

Kazuya Kabayama

Zijian Zhang

Atsushi Shimoyama

Yoshiyuki Manabe

The invention provides a method for producing a solution containingAt(astatide ion) at a high radiochemical purity by usingAt obtained by a nuclear reaction as a starting material, including a step of adding a reducing agent to a solution containing an impurity derived fromAt. The invention also provides a solution containingAt(astatide ion) at a radiochemical purity of not less than 30%.

Astatine solution and method for producing same

The invention relates to a method of producing the radiolabeled aryl compound (I) Ar—X, or a salt thereof, wherein X isAt,At,I,I,I, orI. The method involves reacting the aryl boronic acid compound (II) Ar—Y, or a salt thereof, wherein Y is a borono group (—B(OH)) or an ester group thereof, with a radionuclide selected fromAt,At,I,I,I andI, in the presence of an oxidizing agent selected from an alkali metal iodide, an alkali metal bromide, N-bromosuccinimide, N-chlorosuccinimide and hydrogen peroxide, in water.

Production method for radiolabeled aryl compound

The invention relates to a method of producing the radiolabeled aryl compound (I) Ar&#x2014;X, or a salt thereof, wherein X isAt,At,I,I,I, orI. The method involves reacting the aryl boronic acid compound (II) Ar&#x2014;Y, or a salt thereof, wherein Y is a borono group (&#x2014;B(OH)) or an ester group thereof, with a radionuclide selected fromAt,At,I,I,I andI, in the presence of an oxidizing agent selected from an alkali metal iodide, an alkali metal bromide, N-bromosuccinimide, N-chlorosuccinimide and hydrogen peroxide, in water.

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Suita, Japan

Yoshifumi Shirakami