Nihon Medi-Physics Company, Limited

National Hospital Organization

Yoshifumi Maya

Yuki Okumura

Yoshinari Shoyama

Takako Onishi

Mitsuhide Naruse

Hiroaki Ichikawa

Miho Ikenaga

Yurie Fukui

Akihiro Izawa

Yoshihiro Doi

Hiroyuki Okudaira

Provided are a compound represented by the following formula (1): wherein Xrepresents a hydrogen atom or a halogen atom, Xrepresents a fluorine atom or a nitrile group, and Xrepresents a radioactive halogen atom,

2-[5-(imidazol-1-ylmethyl)pyridin-3-yl]benzimtdazole derivative compound, and medicament including same

A compound represented by the following formula (1), or a salt thereof: wherein Ris a radioactive halogen substituent, 0 to 2 of A, A, Aand Arepresent N, and the rest represent &#x2014;(CH)&#x2014; is effective as a diagnostic imaging probe targeting amyloid. A diagnostic agent for Alzheimer's disease contains a compound represented by the above formula (1) or a salt thereof. After administration to a patient, the compound and the diagnostic agent for Alzheimer's disease transfer into the patient's brain, and indicate good accumulation on amyloid deposited in the brain.

Compound with amyloid affinity

A compound that is effective as a diagnostic imaging probe that targets amyloid including is represented by the following formula (1), or salt thereof: wherein Ris a radioactive halogen substituent, Aand Aindependently represent CH or N. A diagnostic agent for Alzheimer's disease includes the compound represented by the above formula or a salt thereof. The above compound and the above diagnostic agent for Alzheimer's disease transfer into brain after administration, and indicate good accumulation on amyloid deposited in the brain.

Compound having affinity for amyloid

Growing community of inventors

Sodegaura, Japan

Yoshifumi Maya