Fujisawa Pharmaceutical Company, Ltd.

Yoshie Sugiyama

Takao Takaya

Hisashi Takasugi

Atsushi Kuno

Hiroyoshi Sakai

The invention relates to diphenylpyridazine compounds useful in the treatment of cerebrovascular disease, of the formula: ##STR1## wherein R.sup.1 is piperazinyl(lower)alkyl, carbamoyl substituted with piperazinyl(lower)alkyl, or piperazinylcarbonyl, in each of which a piperazinyl group may be substituted with lower alkyl,

Di phenylpyridazine compounds, processes for the preparation thereof and

The invention relates to compounds for treatment of hypertension, and cardiovascular and cerebrovascular diseases, which compounds are of the formula: ##STR1## wherein R.sup.1 is piperazinyl(lower)alkyl, carbamoyl substituted with piperazinyl(lower)alkyl, or piperazinylcarbonyl, in each of which a piperazinyl group may be substituted with lower alkyl, and

Diphenylpyridine compounds, processes for the preparation thereof and

The invention relates to new pyrimidine derivatives, useful in the treatment of cerebrovascular disease, of the formula: ##STR1## wherein Ar, R.sup.1, R.sup.2 and R.sup.3 are defined in the specification.

Pyrimidine derivatives and composition of the same

The invention relates to pyrimidine derivatives and their pharmaceutically acceptable salts which are useful in the treatment of cerebrovascular diseases, to processes for preparation thereof and to the composition containing the same, said pyrimidine derivatives being represented by the following formula: ##STR1## wherein Ar, R.sup.1, R.sup.2 and R.sup.3 are as defined in the disclosure.

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Hyogo, Japan

Yoshie Sugiyama