Nippon Shinyaku Company, Ltd.

Other

Yoshiaki Yoshikuni

Hiroshi Enomoto

Masahiro Yagi

Yoshiaki Aoyagi

Hiromu Murai

Shingo Matsumura

Yoji Ezure

Yukio Fujita

Kohei Kura

Nobutoshi Ojima

Katsuya Ohata

Ichiro Shirahase

Tamiki Mori

Takayuki Ozaki

Koji Kitaguchi

Kenji Sempuku

Yasuo Yasutomi

Akira Hasegawa

Shoichi Chokai

Makoto Sugiyama

Katsuhide Saito

Tatsuhiko Kono

Kazuya Mori

Makoto Kiso

Shigeaki Maruo

Jun Segawa

Hirotsugu Yoshida

Haruo Tanaka

Kiyotaka Konno

Shingo Matsumura, Deceased

Makato Kiso

Katsahide Saito

Moranoline derivative

Lewis-type sugar chain derivative

Compounds are described which are useful for lowering the activity of .alpha..sub.2 -PI, for the treatment of myocardial infarctions and cerebral infarctions, as urokinase secretion accelerators, as antithrombotic agents and to accelerate the fibrinolysis accelerating effect.

Therapeutic agents

Compounds of formula I are useful in the prophylaxis or treatment of hyperglycemic symptoms ##STR1## wherein R is alkyl substituted by one or more hydroxy.

Glucosylmoranoline derivatives and use thereof for inhibiting increase

A compound of formula (I) ##STR1## wherein: B is a divalent substituted or unsubstituted, cyclic or acyclic, saturated or unsaturated hydrocarbon group;

Glucosylmoranoline derivatives

Compounds of formula (I) ##STR1## or a pharmaceutically acceptable salt thereof, wherein R.sup.1 is hydrogen, halogen or alkyl and R.sup.2 is hydrogen or alkyl are useful to reduce serum lipids in animals, including humans.

Benzoic acid derivatives

Abietamide derivatives of the formula I ##STR1## wherein X is NZ wherein Z is hydrogen, alkyl, unsubstituted or substituted phenyl or X is a sulphur atom; when X is NZ, V is nitrogen, W is , and R is hydrogen or alkyl and when X is a sulphur atom, V is  , W is nitrogen, and R is hydrogen, alkyl, phenyl or --CH.sub.2 COOR'; wherein R' is hydrogen or alkyl and  is a single or double bond, are useful for treating hyperlipemia and particularly for the prevention and therapy of arteriosclerosis.

Abietamide derivatives

N-aralkylmoranoline and N-aralkenylmoranoline, and their pharmaceutical acceptable non-toxic acid addition salts thereof, pharmaceutical compositions containing the same and methods of inhibiting the increase in blood sugar level by administration of the same.

Antihyperglycemic moranoline derivatives

Bisglucosyl moranoline of the formula (I) ##STR1## is useful in inhibiting increase of blood sugar in sugar-loaded animals and humans, and particularly for treatment of diabetes mellitus.

Moranoline derivatives

Moranoline, or 2-hydroxymethyl-3,4,5-trihydroxy piperidine, is prepared by directly reducing an actinomycetes culture solution containing nojirimycin, followed by isolation, as for example, through the utilization of an ion exchange resin. The corresponding N-methyl derivative can be obtained through the addition of formaldehyde to the culture solution prior to the reduction.

Method for the production of 2-hydroxymethyl-3,4,5-trihydroxy piperidine

Moranolines are produced which are useful for controlling blood sugar levels.

Moranoline derivatives and process for preparation thereof

Bis(2-hydroxymethyl-3,4,5-trihydroxypiperidine-1-yl-propenyl) compounds and their acid addition salts are antihyperglycemic agents. Typical examples are 1,4-bis[3-(2-hydroxymethyl-3,4,5-trihydroxypiperidin-1-yl)prop-2-enyl] benzene and 1,3-bis-{4-[3-(2-hydroxymethyl-3,4,5-trihydroxy-piperidin-1-yl)prop-2-enyl ]phenoxy}propane.

Bis-piperidine compounds

2-Hydroxymethyl-3,4,5-trihydroxypiperidines bearing a quaternary ammonium-substituted cinnamyl group on the piperidine nitrogen atom and their acid addition salts are antihyperglycemic agents. A typical example is 1-(4-trimethylammoniumcinnamyl)-2-hydroxymethyl-3,4,5-trihydroxypiperidine chloride.

Quaternary ammonium substituted N-cinnamylpiperidines

A process for the preparation of amide derivatives of abietic acid, dehydroabietic acid, dihydroabietic acid or tetrahydroabietic acid which comprises reacting abietic acid, dehydroabietic acid, dihydroabietic acid or tetrahydroabietic acid or a reactive derivative thereof with an amine of the following formula:

Abietamide derivatives, their production and use

Growing community of inventors

Uji, Japan

Yoshiaki Yoshikuni