Takeda Chemical Industries, Inc.

Yoshiaki Uda

Yasuaki Ogawa

Shigeyuki Takada

Takatsuka Yashiki

Shin-Ichiro Hirai

Yukio Fujisawa

Ikuo Nogami

Takamasa Yamaguchi

Toshihiro Ishiguro

Masahide Oka

Masayuki Yamada

Yoko Nishida

Yasushi Nakagawa

Kazuo Nagamatsu

Seizo Kawajiri

Takako Yamauchi

Yoshitsugu Kinoshita

A composition is disclosed comprising a water-insoluble or slightly water-soluble compound and a branched cyclodextrin-carboxylic acid. The branched cyclodextrin-carboxylic acid significantly increases the water-solubility of the compound. Also disclosed is a method of enhancing water-solubility of the compound.

Composition containing a water-insoluble or slightly water-soluble

A novel microparticle preparation comprising microparticles of a polymer which contain a drug and are coated with a film of an agent for preventing aggregation of the microparticles is disclosed. The preparation is produced by spraying a solution of a polymer containing a drug and an aqueous solution of an agent for preventing aggregation of the microparticles separately from different nozzles and contacting them with each other in a spray dryer.

Prolonged release microparticle preparation and production of the same

The present invention relates to a composition for rectal administration which comprises a benzimidazole compound having antiulcer activity and a salt of C.sub.6-20 fatty acid, both of which are intermingled with each other in a base for rectal administration. The composition for rectal administration of the present invention is effective for the treatment of gastrointestinal ulcers, is excellent in the stability of the active ingredient therein and the absorption thereof to thereby insure an early attainment of therapeutically effective blood concentration and permits control of the rate of absorption of the drug. Furthermore, the composition for rectal administration of the present invention swells in the intestinal tract, attaches itself to the mucosa, and releases the active ingredient gradually over a long time to supply the drug at a high concentration and with high efficiency. Therefore, the expected therapeutic efficacy can be obtained at a low dosage level with a minimum of side effect.

Anti-ulcer compositions suitable for rectal administration

A pharmaceutical composition containing a physiologically active peptide or protein which is poorly absorbable through the gastrointestinal tract and heat-labile enterotoxin B subunit brings an increased absorbability of said peptide or protein into the mammalian body when administered through mucosa.

Pharmaceutical composition and its mucosal use

A pharmaceutical composition comprising a slightly water-soluble drug, a cyclodextrin and a water-soluble organic solvent is disclosed. The composition improves water-solubility and stability of the slightly water-soluble drug. The pharmaceutical composition is particularly suitable for injection preparations.

Cyclodextrin composition

A percutaneous pharmaceutical preparation for external use containing N-ethoxycarbonyl-3-morpholinosydnonimine (molsidomine) and an absorption promoter selected from the group consisting of aliphatic monoalcohols of 10 to 22 carbon atoms, aliphatic monoamides of 8 to 18 carbon atoms and aliphatic monoamines of 10 to 16 carbon atoms gives a high blood concentration of molsidomine over a long time period when applied onto the human skin.

Percutaneous pharmaceuticals preparation for external use

A pharmaceutical composition containing a hydrophilic drug which is poorly absorbable through the gastrointestinal tract, and cyclodextrin, increases the absorbability of the drug into the mammalian body when administered by a non-oral or non-injection route.

Pharmaceutical composition and its rectal use

A non-parenteral pharmaceutical preparation containing TRH, its salt, or its analogue is produced by employing the drug and a hydroxycarboxylic acid or polycarboxylic acid of 2 to 8 carbon atoms, and having the pH of the preparation adjusted to 2 to 6.

Pharmaceutical preparations containing TRH or its analogue

An apparatus for sterilization of fluid in sealed containers such as ampoules, the apparatus has a chamber provided with a hot air distributor therein, a magazine conveyor comprising a drum mounted to be rotable about its vertical axis in said chamber having compartment defining means thereon defining a plurality of vertically stacked tiers of compartments for accomodation and transportation of containers to be treated, said chamber having a plurality of bottom walls fixedly mounted therein one being associated with each tier of compartments and constituting the bottoms of said compartments each bottom wall having a gap therein, the gaps being at different circumferential positions, the gaps being for transferring containers inserted and carried in compartments automatically one after the other to the next adjacent lower tier at said positions, one wall of each compartment permitting passage of air therethrough and apparatus for supply and removal of containers to be treated to and from said magazine conveyor, whereby hot air is constantly circulated and recirculated around containers to be treated carried on said magazine conveyor for sterilizing fluid contained in the sealed containers.

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Takarazuka, Japan

Yoshiaki Uda