Mitsui Toatsu Chemicals, Incorporated

Yoshiaki Noguchi

Isamu Yamamoto

Noboru Kawasaki

Eiichi Noda

Kenichi Fujii

Shigenobu Nakayama

Kenichi Arai

Kouzou Iwasaki

The guanidine derivative represented by the formula [III], ##STR1## (commonly known under the name 'Cimetidine') is produced by reaction of the compound represented by the formula [I], ##STR2## with a compound represented by the formula [II], ##STR3## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6, is each hydrogen atom, a lower alkyl group, phenyl group, or a radical of --OR.sub.7 or --COOR.sub.7, in which R.sub.7 is hydrogen atom, a lower alkyl group or an alkali metal, followed by reaction with methylamine.

Process for producing a guanidine derivative

Production of aminoalkylsulfonic acids

A process for producing 2-mercaptoethylamine hydrohalides of the general formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are identical or different, and each represents a hydrogen atom, a lower alkyl group, a hydroxy-substituted lower alkyl group or a phenyl group, and X represents a halogen atom, which comprises reacting a 2-mercaptothiazoline of the general formula ##STR2## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as defined above, with a 2-halogenoethylamine hydrohalide of the general formula ##STR3## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and X are as defined above, in the presence of water.

Process for producing 2-mercaptoethylamine hydrohalides

A process for preparing an organic phosphorous compound of the general formula ##STR1## wherein R.sub.A represents ##STR2## where X.sup.1 is a halogen atom, Y is --CH.sub.2 -- or --CH.sub.2 --C.sub.2 --, and

Process for preparing organic phosphorus compounds

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Yokohama, Japan

Yoshiaki Noguchi