Kurita Water Industries Ltd.

Yoshiaki Motozato

Hiroshi Morita

Masato Yamaguchi

Isao Joko

Takashi Tomoda

Tetsuro Yamamoto

Masaaki Wakita

The separation material for separating and recovering a blood coagulation factor comprises a porous matrix having linked thereon one or more ligands each consisting of a radical exhibiting an affinity for the blood coagulation factor to be recovered, said matrix having a specific surface area of at least 1.5 m.sup.2 per milliliter of the separation material with respect to pores having diameters of at least 0.1 .mu.m and being derived from a porous particulate material having an exclusion limit molecular weight of at least 1.5.times.1.sup.6 as determined with polyethylene glycol. The separation material is prepared by the process steps of subjecting a porous particulate material having an exclusion limit molecular weight of at least 1.5.times.10.sup.6 to activation by 1,1'-carbonyldiimidazolating, tresylating, carbodiimidizing, thiopropylating, epoxidizing, bromocyanizing or formylating using the corresponding activating agent and reacting the so activated porous particulate material with one or more substances which exhibit after being linked as ligand on the porous particulate material, an affinity to the blood coagulation factor to be covered, so as to form a porous matrix having a specific surface area of at least 1.5 m.sup.2 per milliliter of the porous particulate material with respect to pores having diameters of at least 0.1 .mu.m.

Separation material derived from glucomannan for blood coagulation

A novel ion exchanger useful for universal ion-exchange purposes and, in particular, for ion exchanger for ion-exchange chromatography is proposed, said novel ion exchanger being obtained by introducing radicals of one or more ion-exchangeable groups into cross-linked glucomannan beads by a chemical treatment thereof. Such ion exchanger beads are superior in the compressive strength and permit a high flow rate of the liquid to be subjected to ion exchange through an exchange column packed with them.

Ion exchanger based on cross-linked glucomannan

Beads product of Glucomannan having a cross-linked structure and exhibiting a degree of swelling of in the range from 1.5 to 15, an exclusion limit molecular weight in the range from 200 to 100,000,000 and an average bead diameter in the range from 1 to 500 .mu.m. The glucomannan beads are useful for packing material for gel filtration and for gel chromatography. They can be produced by a process which comprises preparing a starting process solution by dissolving an esterified glucomannan solely or together with a diluent in a solvent, introducing this starting process solution into an aqueous medium so as to cause formation of liquid droplets of the starting process solution suspended in said aqueous medium, evaporating off the solvent contained in the liquid droplets to leave spherical beads of the glucomannan ester, saponifying the so formed beads of glucomannan ester to convert into beads of glucomannan and effecting then cross linking of the saponified beads by reacting with a cross linking solvent.

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Kumamoto, Japan

Yoshiaki Motozato