Tokyo Institute of Technology

Nissan Chemical Corporation

Yoshiaki Masaki

Keita Yoshida

Tatsuro Kanaki

Yusuke Iriyama

Kohji Seio

Hiroyuki Nakajima

Keishi Yamamoto

Provided is an artificial nucleoside or artificial nucleotide capable of composing an artificial oligonucleotide having superior nuclease resistance. The artificial nucleoside or artificial nucleotide is a compound represented by formula (I) or a salt thereof (wherein, Bx represents a pyrimidine base or purine base, R, R, Rand Rrepresent hydrogen atoms, C1-6 alkyl groups or the like, Y represents NRR(wherein, Rand R, independently of each other, represent a hydrogen atom, C1-6 alkyl group or the like, or Rand R, together with a nitrogen atom bound thereto, form a 3- to 11-membered nitrogen-containing non-aromatic heterocyclic group) or an optionally substituted C2-9 aromatic heterocyclic group, Zand Zrepresent hydrogen atoms, hydroxyl group-protecting groups, phosphorous-containing groups or the like, and n represents an integer of 1 to 3).

Artificial nucleoside and artificial nucleotide, and artificial oligonucleotide

Growing community of inventors

Tokyo, Japan

Yoshiaki Masaki