Dainippon Sumitomo Pharma Co., Ltd.

Japan Energy Corporation

Sumitomo Dainippon Pharma Co., Ltd.

Sumitomo Pharma Co., Ltd.

Astrazeneca Aktiebolag

Astrazeneca Ab

Yoshiaki Isobe

Stephen Thom

Hidenori Kimura

Hitoshi Watanabe

Ayumu Kurimoto

Haruo Takaku

Masanori Tobe

Haruhisa Ogita

Hitoshi Ban

Yuji Fujiwara

Tetsuhiro Ogino

Yuso Goto

Roger Victor Bonnert

Stephen Brough

Hiroki Wada

Thomas Mcinally

Nobuyoshi Chiba

Osamu Takahashi

Kazuki Hashimoto

Hajime Kawakami

Tomoyuki Tanaka

Hitoshi Fujita

Ian Millichip

Hiroyuki Matsui

Kohsaku Hirota

Hideharu Sato

Hiroaki Tanaka

Hiroyuki Morita

Thomas McInally

Hironao Sajiki

Austen Pimm

Hiroyuki Kitano

Shingo Tojo

Daisuke Urabe

Nicholas James Bennett

Hiroaki Fujiwara

Eiji Ideue

Tomoaki Nakamura

Sumitsugu Kisanuki

Junko Umezawa

Hideyuki Tomizawa

Shun Narai

Hirotaka Miyachi

Yoshikazu Matsuda

Junko Matsui

Akihisa Yokoyama

Harumi Satoh

Fumihiro Obara

Nobuo Watanabe

Masashi Sasaki

Toshimasa Katagiri

Yoichi Ohba

The present invention provides a compound of the formula (1):

Substituted pyrimidines as vaccine adjuvants

The present invention provides a compound of the formula (1): wherein X, R, R, R, R, R, R, Y, Y, L, and m are as defined in the description, and a pharmaceutically acceptable salt thereof, which are useful as a vaccine adjuvant.

The present invention provides a compound of formula (1) and a pharmaceutical composition comprising the compound useful as a nerve regeneration promoter wherein R-L- is R&#x2014;OC(O)&#x2014;, or the like, Ris hydrogen atom, optionally-substituted Calkyl group, optionally-substituted 3- to 8-membered cycloalkyl group, or the like, Ris hydrogen atom or the like, Ring A is formula (2) or formula (3) wherein Ris hydrogen atom, optionally-substituted Calkyl group, or the like, the part of X, Y, and Z is X&#x2550;Y&#x2014;Z, X&#x2014;Y&#x2550;Z, or X&#x2014;Y&#x2014;Z, X is nitrogen atom, NR(Ris hydrogen atom, optionally-substituted Calkyl group, or the like), or the like, Y is carbon atom or the like, and Z is carbon atom, nitrogen atom or the like.

Biheterocyclic compound

The present invention relates to a compound of formula (1) wherein Qis halogen atom, Qis hydrogen atom, etc., X, Y, and Z are nitrogen atom or oxygen atom, and Rhas a given structure, or a pharmaceutically acceptable salt thereof, and a medicament comprising the compound for treating and/or preventing a disease such as epilepsy.

Oxadiazole derivative

The present invention relates to a medicament for treating various nervous system diseases or psychiatric diseases, comprising a compound of formula (1) or a pharmaceutically acceptable salt thereof as an active ingredient, wherein Ris hydrogen, etc., Ris halogen, etc., R, R, R, and Rare hydrogen, etc. 

Benzisoxazole derivative

The present invention provides a compound of the formula (2): 

The present invention relates to a substituted purine derivative of formula (1) wherein Ris alkoxy or the like, Ris alkyl or the like, Ring Qis aryl or the like, Wis alkylene or the like, Ring Qis aromatic carbocyclyl or the like, n is 1-4, Ris hydrogen atom or the like, Xis single bond or the like, Wis alkylene or the like, and Ris hydrogen atom or the like, or a pharmaceutically acceptable salt thereof, which has a potent inhibitory effect against TLR7, and thereby is useful for treating autoimmune disease. 

Substituted purine derivative

Pyrimidine compounds and their use as vaccine adjuvants

The present invention provides an 8-oxoadenine compound having immunomodulating activities such as an interferon inducing activity and useful as an antiviral agent and antiallergic agent, which is represented by the following formula (1): [wherein the ring A represents a 6-10 membered aromatic carbocyclic ring and the like, R represents a halogen atom, an alkyl group and the like, n represents an integer of 0-2, Zrepresents alkylene, Xrepresents oxygen atom, sulfur atom, SO, NR, CO, CONR, NRCO and the like, Y, Yand Yrepresent independently a single bond or an alkylene group, Xrepresents oxygen atom, sulfur atom, NR(Ris hydrogen atom or an alkyl group) or a single bond, Rrepresents a substituted or unsubstituted alkyl group, Rrepresents hydrogen atom, hydroxy group, an alkoxy group, an alkoxycarbonyl group or a haloalkyl group]or its pharmaceutically acceptable salt.

9-substituted 8-oxoadenine compound

The present invention provides an 8-oxoadenine compound having immunemodulating activities such as an interferon inducing activity and useful as an antiviral agent and antiallergic agent, which is represented by the following formula (1): [wherein the ring A represents a 6-10 membered aromatic carbocyclic ring and the like, R represents a halogen atom, an alkyl group and the like, n represents an integer of 0-2, Zrepresents alkylene, Xrepresents oxygen atom, sulfur atom, SO, NR, CO, CONR, NRCO and the like, Y, Yand Yrepresent independently a single bond or an alkylene group, Xrepresents oxygen atom, sulfur atom, NR(Ris hydrogen atom or an alkyl group) or a single bond, Rrepresents a substituted or unsubstituted alkyl group, Rrepresents hydrogen atom, hydroxy group, an alkoxy group, an alkoxycarbonyl group or a haloalkyl group]or its pharmaceutically acceptable salt.

The invention provides salts of 4-(dimethylamino)butyl 2-(4-((2-amino-4-methyl-6-(pentylamino)pyrimidin-5-yl)methyl)phenyl)acetate, pharmaceutical compositions containing them and their use in therapy.

Salts 756

A drug for topically administration which is effective as an antiallergic agent. The drug for topically administration contains as an active ingredient an adenine compound represented by the general formula (1): [wherein ring A represents a 6 to 10 membered, mono or bicyclic, aromatic hydrocarbon or a 5 to 10 membered, mono or bicyclic, aromatic heterocycle containing one to three heteroatoms selected among 0 to 2 nitrogen atoms, 0 or 1 oxygen atom, and 0 or 1 sulfur atom; n is an integer of 0 to 2; m is an integer of 0 to 2; R represents halogeno, (un)substituted alkyl, etc.; Xrepresents oxygen, sulfur, NR(Rrepresents hydrogen or alkyl), or a single bond; Yrepresents a single bond, alkylene, etc.; Yrepresents a single bond, alkylene, etc.; Z represents alkylene; and at least one of Qand Qrepresents &#x2014;COOR(wherein Rrepresents (un)substituted alkyl, etc.), etc.] or a pharmaceutically acceptable salt of the compound.

Adenine compound and use thereof

Growing community of inventors

Osaka, Japan

Yoshiaki Isobe